{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:46:18Z","timestamp":1782517578001,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["209933838\u2010SFB 1052 project C05"],"award-info":[{"award-number":["209933838\u2010SFB 1052 project C05"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["209933838\u2010SFB 1052 project C09"],"award-info":[{"award-number":["209933838\u2010SFB 1052 project C09"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01GL2405A"],"award-info":[{"award-number":["01GL2405A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010215","name":"Deutsche Diabetes Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010215","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["MV22\/00010"],"award-info":[{"award-number":["MV22\/00010"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019173","name":"Roland Ernst Stiftung","doi-asserted-by":"publisher","award":["01\/25"],"award-info":[{"award-number":["01\/25"]}],"id":[{"id":"10.13039\/501100019173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The lipid droplet\u2013associated hydrolase (LDAH) is a lipid droplet\u2013associated protein with an uncharacterized role in human adipose tissue (AT) and obesity; we aimed to investigate its role in human AT and its relevance for childhood obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>LDAH<\/jats:italic>\n                      variant rs13385191 and gene expression were analyzed in a cross\u2010sectional study of subcutaneous AT samples from 296 children (120 girls, 176 boys; ages 0\u201318; BMI SDS \u22122.7 to 4.3), and an association with obesity and AT biology was studied. An effect of\n                      <jats:italic>LDAH<\/jats:italic>\n                      on adipogenesis was investigated in SGBS preadipocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Minor allele carriers of rs13385191 showed lower AT\n                      <jats:italic>LDAH<\/jats:italic>\n                      expression compared to non\u2010carriers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a trend toward higher BMI SDS, which was, however, not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.062). Consistently, study participants with lower\n                      <jats:italic>LDAH<\/jats:italic>\n                      expression showed higher BMI SDS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). A negative correlation was found between\n                      <jats:italic>LDAH<\/jats:italic>\n                      and macrophage infiltration into AT after controlling for age (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u2009\u22120.132;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039), and high\n                      <jats:italic>LDAH<\/jats:italic>\n                      expression was associated with lower circulating TNF\u03b1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017).\n                      <jats:italic>LDAH<\/jats:italic>\n                      expression increased during SGBS adipocyte differentiation, while its knockdown did not alter differentiation. In line with results from AT, TNF\u03b1 significantly reduced\n                      <jats:italic>LDAH<\/jats:italic>\n                      expression in SGBS cells (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LDAH seems to have a role in AT inflammation and the development of obesity in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70216","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T13:25:42Z","timestamp":1779974742000},"page":"1420-1432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Lipid Droplet\u2013Associated Hydrolase Is Associated With Obesity and Adipose Tissue Inflammation in Children"],"prefix":"10.1002","volume":"34","author":[{"given":"Claudia","family":"Vales\u2010Villamar\u00edn","sequence":"first","affiliation":[{"name":"Center for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Berthold","sequence":"additional","affiliation":[{"name":"Center for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lacher","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"K\u00f6rner","sequence":"additional","affiliation":[{"name":"Center for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty University of Leipzig  Leipzig Germany"},{"name":"Helmholtz Institute for Metabolic Obesity and Vascular Research (HI\u2010MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig  Leipzig Germany"},{"name":"LIFE\u2013Leipzig Research Center for Civilization Diseases Medical Faculty, University of Leipzig  Leipzig Germany"},{"name":"German Center of Child and Adolescent Health (DZKJ) Leipzig\/Dresden and Munich Partner Sites  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6878-6033","authenticated-orcid":false,"given":"Kathrin","family":"Landgraf","sequence":"additional","affiliation":[{"name":"Center for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty University of Leipzig  Leipzig Germany"},{"name":"Helmholtz Institute for Metabolic Obesity and Vascular Research (HI\u2010MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig  Leipzig Germany"},{"name":"German Center of Child and Adolescent Health (DZKJ) Leipzig\/Dresden and Munich Partner Sites  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization (WHO) \u201cObesity and Overweight \u201dupdated December 8 2025 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight."},{"key":"e_1_2_9_3_1","volume-title":"Report on the Sixth Round of Data Collection, 2022\u20132024","author":"WHO European Childhood Obesity Surveillance Initiative (COSI)","year":"2025"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0744"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803527"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06283-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12904"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.12.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092358"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0085-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2023.01.018"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12717"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302448"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy310"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201002963\u2010y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M072538"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-025-00566-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050949\u2010y"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.5.3075"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037866"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.12.058"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002078"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227072"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.635"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23202"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0870-T"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0694-T"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009218"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3768"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001120170107"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab630"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801520"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2773-0"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108295"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2323\/jgam.2017.08.001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M050229"},{"key":"e_1_2_9_39_1","first-page":"2198","article-title":"The Evolutionarily Conserved Protein CG9186 Is Associated With Lipid Droplets, Required for Their Positioning and for Fat Storage","volume":"126","author":"Thiel K.","year":"2013","journal-title":"Journal of Cell Science"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1153915"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.70216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:00:51Z","timestamp":1782514851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.70216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/oby.70216"],"URL":"https:\/\/doi.org\/10.1002\/oby.70216","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"2025-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}