{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:15:09Z","timestamp":1788340509235,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the association of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) with risks of osteoporosis, major osteoporotic fractures, and degenerative musculoskeletal disorders in nondiabetic adults with obesity compared with other obesity medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included deidentified TriNetX data on \u2265\u200950\u2010year\u2010old nondiabetic adults with obesity. After 1:1 propensity score matching on demographic, clinical, and laboratory covariates, 18,062 GLP\u20101 RA users were compared with non\u2010GLP\u20101 medication users. The primary outcome was incident osteoporosis; secondary outcomes included major osteoporotic fractures, cervical and thoracolumbar disc disorders, and osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GLP\u20101 RA use was associated with lower risks of osteoporosis (relative risk [RR] 0.48; 95% CI, 0.43\u20130.52; number needed to treat [NNT]\u2009=\u200928), major osteoporotic fractures (RR 0.15; 95% CI, 0.11\u20130.22; NNT\u2009=\u200988), cervical disc degeneration (RR 0.34; 95% CI, 0.28\u20130.41; NNT\u2009=\u200963), thoracolumbar disc disease (RR 0.36; 95% CI, 0.33\u20130.40; NNT\u2009=\u200920), and osteoarthritis (RR 0.45; 95% CI, 0.43\u20130.48; NNT\u2009=\u20099). Protective associations were consistent across age, sex, BMI, and drug subtype subgroups and remained robust in sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RA use was associated with favorable musculoskeletal outcomes, including lower risks of osteoporosis and fractures, in nondiabetic adults with obesity compared with other obesity medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70218","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:01:29Z","timestamp":1780358489000},"page":"119-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Musculoskeletal Outcomes of Glucagon\u2010Like Peptide\u20101 Receptor Agonists Versus Other Antiobesity Agents in Nondiabetic Adults"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8164-3299","authenticated-orcid":false,"given":"Jie\u2010Syuan","family":"Wu","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7212-3535","authenticated-orcid":false,"given":"Lee\u2010Yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8018-8847","authenticated-orcid":false,"given":"Jia\u2010Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ting","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-1130","authenticated-orcid":false,"given":"Fara Silvia","family":"Yuliani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-560X","authenticated-orcid":false,"given":"Shyh\u2010Hsiang","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Nutrition, College of Nutrition, Taipei Medical University  Taipei Taiwan"},{"name":"School of Food Safety, College of Nutrition, Taipei Medical University  Taipei 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