{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:46:17Z","timestamp":1782517577512,"version":"3.54.5"},"reference-count":82,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Obesity and its related metabolic diseases, such as metabolic dysfunction\u2010associated steatotic liver disease (MASLD), represent a major global health challenge. Mitochondrial dysfunction is a key driver in their pathogenesis. This review explores the emerging role of mitochondrial transfer, a novel mode of cellular communication that can occur via tunneling nanotubes, extracellular vesicles, or as free mitochondria, in these conditions. Increasing evidence suggests that mitochondrial transfer may contribute to tissue homeostasis and metabolic adaptation, and that disruption of this process may participate in the pathogenesis of obesity and MASLD. In parallel, therapeutic strategies aimed at restoring mitochondrial function by enhancing endogenous mitochondrial transfer or through mitochondrial transplantation are beginning to emerge. This review summarizes current knowledge of the mechanisms underlying mitochondrial transfer, discusses roles in obesity and MASLD, and evaluates the therapeutic potential and translational challenges of targeting mitochondrial transfer in obesity and obesity\u2010related metabolic disease.<\/jats:p>","DOI":"10.1002\/oby.70223","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:50:12Z","timestamp":1778503812000},"page":"1369-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial Transfer: A Novel Mechanism in the Development of Obesity and Obesity\u2010Related Metabolic Diseases"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7269-4299","authenticated-orcid":false,"given":"Lei","family":"Zhu","sequence":"first","affiliation":[{"name":"Eight\u2010Year Program of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"},{"name":"Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission Translation Medicine Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission Translation Medicine Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission Translation Medicine Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Complex, Severe, and Rare Diseases Biomedical Engineering Facility of National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6361-3811","authenticated-orcid":false,"given":"Fengying","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission Translation Medicine Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5172-6870","authenticated-orcid":false,"given":"Huijuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission Translation Medicine Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)02403\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12061172"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(22)00317\u2010X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.09.020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010330595"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006537\u2010z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510511103"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009176\u20108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008439\u20100"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.02.016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18928"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093133"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1682"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063245"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102798"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010023\u201000556\u20105"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201386030"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.29400"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252313034"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201005\u2010573543"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.08.002"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.08.010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901917RR"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.008"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900942"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010023\u201000498\u2010x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.13076"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.10.005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.035"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057444\u2010y"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111948"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.320458"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.10.015"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203357"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2023.71343.15525"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010024\u201004064\u20100"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117177"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.786671"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.96508"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.030"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2024.101856"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.115154"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010024\u201003932\u20109"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj0534"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201005768\u20106"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201018\u20100773"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201064486\u20109"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000682\u2010z"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.1.395"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.2.727"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/295605a0"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2025.04.002"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897221148457"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015\u20100010"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.09.012"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ard.2024.11.005"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201003219\u2010x"},{"key":"e_1_2_9_60_1","doi-asserted-by":"crossref","unstructured":"M.Namwanje S.Mazumdar A.Stayton et\u00a0al. \u201cExogenous Mitochondrial Transfer Increases Energy Expenditure and Attenuates Adiposity Gains in Mice With Diet\u2010Induced Obesity \u201dbioRxiv 2023.12.23.573206 (2023) https:\/\/doi.org\/10.1101\/2023.12.23.573206.","DOI":"10.1101\/2023.12.23.573206"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00241"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8090350"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010021\u201002663\u20105"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122116"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011403"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14156"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3479"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08780"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00883.2012"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.10.077"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2018.03.002"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121622"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5605"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.11.172"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.52570"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.38104"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010018\u20101012\u20100"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.323800"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.212712"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018317"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010025\u201000411\u20106"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.08.017"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402035"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.70223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:00:38Z","timestamp":1782514838000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.70223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":82,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/oby.70223"],"URL":"https:\/\/doi.org\/10.1002\/oby.70223","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"2025-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}