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FA, eating motives, mindful eating, BMI\u00a0\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score, fat content, and visceral fat level were assessed. Analyses utilized structural equation modeling, latent growth modeling, and voxel\u2010based morphometry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2071 screened, 1601 youth (55.5% boys; mean age\u2009=\u200912.69\u2009\u00b1\u20093.04\u2009years) completed the baseline survey, with 880 and 564 completing the 6\u2010 and 12\u2010month follow\u2010ups, respectively. FA mediated the relationship between eating motives and weight status, and mindful eating moderated this pathway (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Longitudinally, baseline FA predicted accelerated accumulation of fat content and visceral fat level, but not BMI\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The independent 75\u2010MRI sample revealed that left insula gray\u2010matter volume was negatively associated with FA but positively associated with mindful eating.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FA may link eating motives to fat accumulation in youth, particularly abdominal fat; mindful eating may be protective, with left insula structure and left insula\u2010striatum connectivity as possible neural correlates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70225","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T06:40:33Z","timestamp":1780296033000},"page":"1433-1445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Food Addiction Risk Accelerates Fat Accumulation in Youth: Potential Protective Roles of Left Insula and Mindful Eating"],"prefix":"10.1002","volume":"34","author":[{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-4615","authenticated-orcid":false,"given":"Ke","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Ye","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University  Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nursing Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases  Hangzhou 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