{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:46:20Z","timestamp":1782517580664,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD0550504"],"award-info":[{"award-number":["2025ZD0550504"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370901"],"award-info":[{"award-number":["82370901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["24DZ2304800"],"award-info":[{"award-number":["24DZ2304800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obesity, a critical public health challenge, involves dysregulated food stimuli responses central to its pathophysiology. Aversion to harmful food is protective, but dynamic brain network reorganization during aversion processing in obesity and its clinical implications remain inadequately understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Brain activity was recorded from 30 participants with obesity and 35 healthy participants during exposure to spoiled food videos in an MRI scanner. We applied dynamic network analysis to assess obesity\u2010related alterations in neural circuits and their links to eating disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The group with obesity showed significantly lower integration between the visual (VN), dorsal attention (DAN), and subcortical (SUB) networks than the healthy control group while viewing spoiled food videos. Critically, this DAN\u2010SUB integration correlated positively with body image distress and negatively with craving ratings, and it moderated the predictive link between cognitive impulsivity and eating disorders. Granger causality analysis confirmed a dominant indirect pathway with stronger effective connectivity, showing differential spatial associations with neurotransmitter receptors (\u03b14\u03b22, mGluR5, NMDA, and CB1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reveals VN\u2010DAN\u2010SUB dynamic interactions in aversion processing, emphasizing the indirect pathway's key role. Inefficient VN\u2010DAN\u2010SUB coordination in obesity may impair aversive food stimuli regulation, supporting the emotion regulation deficit hypothesis and offering a neurobiological basis for future interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70226","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:45:09Z","timestamp":1781484309000},"page":"1446-1456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Network Reconfiguration of Brain Function During Exposure to Aversive Stimuli"],"prefix":"10.1002","volume":"34","author":[{"given":"Zhoukang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Metabolic &amp; Bariatric Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychology Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9735-5657","authenticated-orcid":false,"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Metabolic &amp; Bariatric Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital  Shanghai China"},{"name":"Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Centre for Mental Disorders, Shanghai Mental Health Centre Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjiecheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Metabolic &amp; Bariatric Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Metabolic &amp; Bariatric Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"MR Collaborations Siemens Healthcare Ltd.  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