{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:23:45Z","timestamp":1792034625027,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study assessed the impact of sex and age on weight loss outcomes in patients receiving tirzepatide in real\u2010world clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of adults with overweight or obesity who initiated tirzepatide at Mayo Clinic between June 2022 and May 2024 and completed \u2265\u200912\u2009months of continuous therapy. Primary outcome was total body weight loss percentage (TBWL%) at 15\u2009months, stratified by sex and age groups (\u2264\u200945, 46\u201359, \u2265\u200960\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1039 patients (57% women; mean age 56\u2009\u00b1\u200911\u2009years), women achieved significantly greater TBWL% than men after 15\u2009months of treatment (15.1% vs. 10.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients aged \u2264\u200945\u2009years had greater weight loss than those \u2265\u200960\u2009years (15.1% vs. 12.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024). In multivariable analyses, greater weight loss was independently associated with female sex, absence of type 2 diabetes, no prior obesity medication use, no concomitant weight gain\u2010promoting medications, and higher tirzepatide dosage. Age was not an independent predictor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sex, but not age, predicted weight loss with tirzepatide among individuals using the medication continuously for \u2265\u200912\u2009months. These findings underscore the importance of incorporating sex\u2010specific considerations into personalized obesity treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70231","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:02:16Z","timestamp":1781503336000},"page":"132-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex, Not Age, Predicts Weight Loss Outcomes With Tirzepatide: A Retrospective Analysis"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4735-6609","authenticated-orcid":false,"given":"Regina","family":"Castaneda","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9585-5111","authenticated-orcid":false,"given":"Dima","family":"Bechenati","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3349-3676","authenticated-orcid":false,"given":"Rene de J.","family":"Rivera Gutierrez","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-6210","authenticated-orcid":false,"given":"Maria A.","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota 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L.","family":"Meek","sequence":"additional","affiliation":[{"name":"Department of Education Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-0191","authenticated-orcid":false,"given":"Kristin C.","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-9102","authenticated-orcid":false,"given":"Stacey J.","family":"Winham","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-5081","authenticated-orcid":false,"given":"Tamim I.","family":"Rajjo","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Mayo 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