{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:42Z","timestamp":1785437982318,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031198","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020578","name":"Department of Jobs, Tourism, Science and Innovation, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020578","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obesity, particularly excess visceral adipose tissue (VAT), may accelerate biological aging; however, few studies have examined this in middle\u2010aged adults. We investigated associations between dual\u2010energy X\u2010ray absorptiometry (DXA)\u2010derived VAT and two biomarkers of biological aging\u2014phenotypic age acceleration (PhenoAgeAccel) and leukocyte telomere length (LTL)\u2014in 4799 participants (2614 females, aged 45\u201369\u2009years) from the Busselton Healthy Ageing Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Whole\u2010body DXA (GE Lunar) quantified VAT mass. Phenotypic age was estimated from chronological age and nine biomarkers. In a subsample of 1221 participants, LTL was measured as the telomeric DNA to single\u2010copy gene (\n                      <jats:italic>T<\/jats:italic>\n                      \/\n                      <jats:italic>S<\/jats:italic>\n                      ) ratio. Sex\u2010stratified linear regressions assessed associations, adjusting for chronological age and lifestyle factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean\u2009\u00b1\u2009SD VAT mass was 1677\u2009\u00b1\u2009873\u2009g in males and 882\u2009\u00b1\u2009598\u2009g in females. Higher VAT was associated with greater PhenoAgeAccel in both sexes; each 1\u2010SD increase in VAT corresponds to 1.397 (95% CI 1.197, 1.596) and 1.919 (1.738, 2.099) years higher PhenoAgeAccel in males and females, respectively. In females only, higher VAT was associated with shorter LTL (\u22120.041 [\u22120.069, \u22120.013] per 1 SD). Associations mostly remained significant after adjustment for anthropometric and other DXA\u2010derived adiposity measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VAT may represent a specific marker of accelerated biological aging, independent of lifestyle and adiposity measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70239","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T23:06:43Z","timestamp":1782688003000},"page":"1613-1622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>DXA<\/scp>\n                    \u2010Measured Visceral Adipose Tissue and Accelerated Biological Aging in Middle\u2010Aged Adults"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1460-9847","authenticated-orcid":false,"given":"Riorden","family":"O'Shea","sequence":"first","affiliation":[{"name":"WA Country Health Service  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-2496","authenticated-orcid":false,"given":"Jennie","family":"Hui","sequence":"additional","affiliation":[{"name":"School of Population and Global Health University of Western Australia  Perth Australia"},{"name":"Busselton Population Medical Research Institute  Busselton Australia"},{"name":"Department of Diagnostic Genomics PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrianna","family":"Bharat","sequence":"additional","affiliation":[{"name":"School of Population and Global Health University of Western Australia  Perth Australia"},{"name":"Busselton Population Medical Research Institute  Busselton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Murray","sequence":"additional","affiliation":[{"name":"School of Population and Global Health University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Arscott","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Genomics PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hunter","sequence":"additional","affiliation":[{"name":"School of Population and Global Health University of Western Australia  Perth Australia"},{"name":"Busselton Population Medical Research Institute  Busselton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Walsh","sequence":"additional","affiliation":[{"name":"Medical School The University of Western Australia  Perth Australia"},{"name":"Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical School The University of Western Australia  Perth Australia"},{"name":"Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital  Perth 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