{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:19:59Z","timestamp":1791209999063,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR001446"],"award-info":[{"award-number":["KL2TR001446"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["L30DK144880"],"award-info":[{"award-number":["L30DK144880"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Directly compare the real\u2010world effectiveness of semaglutide and tirzepatide to bariatric operations: sleeve gastrectomy and gastric bypass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included adults with BMI \u2265\u200935 who received injectable semaglutide or tirzepatide (GLP\u20101RAs) or sleeve gastrectomy or gastric bypass (bariatric surgery) at two urban health systems from 2018 to 2024. Total weight loss (TWL) was compared up to 3\u2009years post treatment with inverse probability weighting and mixed linear models. Intention\u2010to\u2010treat (any GLP\u20101RA) and per\u2010protocol (1\u2009year of continuous GLP\u20101RA orders) analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 44,025 patients studied, bariatric surgery was associated with greater weight loss at 1, 2, and 3\u2009years post treatment: semaglutide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925,804) TWL (95% CI): 5.4% (5.3%\u20135.6%), 6.5% (6.4%\u20136.7%), and 7.4% (7.3%\u20137.6%); tirzepatide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097308): 9.1% (8.9%\u20139.4%) and 10.8% (10.2%\u201311.3%); sleeve gastrectomy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098728): 24.4% (24.3%\u201324.6%), 22.4% (22.3%\u201322.5%), and 22.0% (21.8%\u201322.1%); gastric bypass (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092185): 29.8% (29.7%\u201329.9%), 28.1% (28.0%\u201328.2%), and 28.4% (28.3%\u201328.5%). With 1\u2009year of continuous GLP\u20101RA, findings were: semaglutide TWL: 7.2% (7.0%\u20137.4%), 8.0% (7.8%\u20138.2%), and 8.8% (8.6%\u20139.0%); tirzepatide TWL: 11.7% (11.4%\u201311.9%) and 11.9% (11.5%\u201312.3%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective two\u2010center study, bariatric surgery was associated with greater weight loss than GLP\u20101RAs among patients eligible for both options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70246","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:26:29Z","timestamp":1782393989000},"page":"1583-1591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010World Effectiveness of Semaglutide and Tirzepatide Compared With Bariatric Surgery"],"prefix":"10.1002","volume":"34","author":[{"given":"Avery","family":"Brown","sequence":"first","affiliation":[{"name":"Division of Bariatric and General Surgery NYC Health+Hospitals\/Bellevue  New York New York USA"},{"name":"Department of Surgery NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhani S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery NYU Grossman School of Medicine  New York New York USA"},{"name":"Center for Surgical and Transplant Applied Research NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-9674","authenticated-orcid":false,"given":"Akio","family":"Kozato","sequence":"additional","affiliation":[{"name":"Division of Bariatric and General Surgery NYC Health+Hospitals\/Bellevue  New York New York USA"},{"name":"Department of Surgery NYU Grossman 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