{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:56Z","timestamp":1785437996671,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the associations between per\u2010 and polyfluoroalkyl substances (PFAS) and distinct obesity\u2010metabolic phenotypes and explore underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 8692 adults from NHANES 2003\u20132018 were classified into four phenotypes as follows: metabolically healthy obesity (MHO), metabolically unhealthy obesity (MUO), metabolically healthy non\u2010obesity (MHNO), and metabolically unhealthy non\u2010obesity (MUNO). Multiple statistical models were used to evaluate the associations between PFAS exposure and distinct phenotypes. Network toxicology and molecular docking were employed for mechanistic exploration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Logistic regression analyses showed congener\u2010specific associations of PFAS with MHO, MUO, and MUNO. PFUA was inversely associated with all three phenotypes (OR\u2009=\u20090.60, 0.55, and 0.79, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Weighted quantile sum (WQS), quantile g\u2010computation (Qgcomp), and Bayesian kernel machine regression (BKMR) analyses consistently indicated the negative associations of PFAS mixture exposure with MHO (OR\n                      <jats:sub>WQS<\/jats:sub>\n                      \u2009=\u20090.67, log[OR]\n                      <jats:sub>Qgcomp<\/jats:sub>\n                      \u2009=\u2009\u22120.48;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and MUO (OR\n                      <jats:sub>WQS<\/jats:sub>\n                      \u2009=\u20090.81, log[OR]\n                      <jats:sub>Qgcomp<\/jats:sub>\n                      \u2009=\u2009\u22120.24;\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001). Stratified BKMR suggested the inverse PFAS\u2010BMI relationship was independent of metabolic status. The peroxisome proliferator\u2010activated receptor signaling pathway was predicted to link PFAS and obesity\u2010metabolic phenotypes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although PFAS mixture exposure may not increase the risks of obesity and metabolic abnormalities, congener\u2010specific effects on distinct phenotypes indicate the necessity of analyzing specific compositional profiles of PFAS exposure when evaluating endocrine toxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70259","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:57:48Z","timestamp":1783738668000},"page":"1655-1668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Congener\u2010Specific Associations of Per\u2010 and Polyfluoroalkyl\u00a0Substances With Obesity\u2010Metabolic Phenotypes: A Multimodel Analysis"],"prefix":"10.1002","volume":"34","author":[{"given":"Liyun","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases The First Affiliated Hospital of China Medical University  Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, School of Basic Medicine China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingrui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases The First Affiliated Hospital of China Medical University  Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases The First Affiliated Hospital of China Medical University  Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases The First Affiliated Hospital of China Medical University  Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases The First Affiliated Hospital of China Medical University  Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases The First Affiliated Hospital of China Medical University  Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases The First Affiliated Hospital of China Medical University  Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3681-4095","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases The First Affiliated Hospital of China Medical University  Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ieam.258"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152565"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-023-00601-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1EM00228G"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c04844"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108569"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107584"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.176187"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2026.1768277"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.7270"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12549"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20263"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.2145"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0594"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487315623884"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30329"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuu007"},{"issue":"168","key":"e_1_2_11_20_1","article-title":"National 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