{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:20:48Z","timestamp":1787757648553,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010710","name":"Dairy Farmers of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 2018\u20104238"],"award-info":[{"award-number":["RGPIN 2018\u20104238"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Dairy consumption plays a protective role in obesity that may be mediated through the gut microbiota. This study examined the role of dairy proteins, casein, whey, and complete dairy (skim milk powder), and a plant\u2010based alternative, soy, on gut microbiota composition, obesity susceptibility, and insulin sensitivity in early development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following weaning, rat pups were randomized into four isocaloric diets (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098\u201311\/sex\/diet) for 4\u2009weeks: (1) complete dairy; (2) casein; (3) whey; and (4) soy. Primary outcomes included food intake, growth, body composition, glucose tolerance, and fecal microbiota composition. Animals were then metabolically challenged with a high\u2010fat, high\u2010sucrose diet (HFHS, 40% kilocalories from fat) for 5\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The impacts on gut microbiota and metabolic outcomes were sex and protein dependent. Compared to casein, complete dairy consumption reduced diversity, while early exposure to complete dairy improved body fat percentage but not glucose tolerance or insulin sensitivity. Soy elicited differential effects in males and females. Despite preserved microbial patterns, diets were unable to overcome the detrimental metabolic impacts of HFHS diet exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results show that complete dairy positively modulates gut microbial profiles and benefits\u00a0body composition early in life, but it could not curtail the negative metabolic impacts of HFHS feeding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70266","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:47:35Z","timestamp":1786355255000},"page":"1772-1784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early\u2010Life Dietary Protein Source Reshapes Gut Microbiota but Fails to Curtail Diet\u2010Induced Metabolic Syndrome in Young Rats"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9405-5907","authenticated-orcid":false,"given":"Chunlong","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Infectious Diseases, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Biochemistry and Molecular Biology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"},{"name":"Libin Cardiovascular Institute University of Calgary  Calgary Alberta Canada"},{"name":"Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Hartslief","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Cumming School of Medicine University of Calgary  Calgary 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Wright","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Faculty of Land &amp; Food Systems University of British Columbia  Vancouver British Columbia Canada"},{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Shearer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"},{"name":"Libin Cardiovascular Institute University of Calgary  Calgary Alberta Canada"},{"name":"Faculty of Kinesiology University of Calgary  Calgary Alberta 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