{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:21:47Z","timestamp":1787757707723,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["CS\u2010114\u2010PP\u201014"],"award-info":[{"award-number":["CS\u2010114\u2010PP\u201014"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\u20102314\u2010B\u2010182\u2010036\u2010MY3"],"award-info":[{"award-number":["112\u20102314\u2010B\u2010182\u2010036\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113\u20102314\u2010B\u2010182A\u2010062\u2010MY3"],"award-info":[{"award-number":["113\u20102314\u2010B\u2010182A\u2010062\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["114\u20102314\u2010B\u2010182A\u2010025\u2010"],"award-info":[{"award-number":["114\u20102314\u2010B\u2010182A\u2010025\u2010"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3P0591"],"award-info":[{"award-number":["CMRPG3P0591"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3N0672"],"award-info":[{"award-number":["CMRPG3N0672"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG5M0041"],"award-info":[{"award-number":["CMRPG5M0041"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3N0652"],"award-info":[{"award-number":["CMRPG3N0652"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG3P0302"],"award-info":[{"award-number":["CORPG3P0302"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPVVN0221"],"award-info":[{"award-number":["CMRPVVN0221"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPVVN0232"],"award-info":[{"award-number":["CMRPVVN0232"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3N0961"],"award-info":[{"award-number":["CMRPG3N0961"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG3N0481"],"award-info":[{"award-number":["CORPG3N0481"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3K1701"],"award-info":[{"award-number":["CMRPG3K1701"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      <jats:italic>VTRNA2\u20101<\/jats:italic>\n                      is a metastable epiallele whose methylation is associated with metabolic homeostasis via PKR\u2010mediated inflammation and adipocyte function. We aimed to determine whether preoperative\n                      <jats:italic>VTRNA2\u20101<\/jats:italic>\n                      promoter methylation in peripheral blood predicts long\u2010term excess weight loss (%EWL) after bariatric surgery. We explored transcriptional signatures in adipose tissue to clarify the relationship between early\u2010life epigenetic imprinting on adult metabolic plasticity and surgical outcomes in patients with severe obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In the OCEAN prospective registry (2011\u20132024), 179 adults underwent bariatric surgery. Peripheral blood DNA\n                      <jats:italic>VTRNA2\u20101<\/jats:italic>\n                      methylation was classified as hypo\u2010, intermediate, or hyper\u2010methylated. %EWL was recorded at 3, 6, 12, and 24\u2009months. Adipose tissue was assayed for\n                      <jats:italic>IL13<\/jats:italic>\n                      ,\n                      <jats:italic>PRDM16<\/jats:italic>\n                      , and related transcripts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>VTRNA2\u20101<\/jats:italic>\n                      methylation showed a bimodal distribution, differing significantly from controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Hypermethylated patients had lower\n                      <jats:italic>VTRNA2\u20101<\/jats:italic>\n                      expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and greater %EWL at 12 (67.8%\u2009\u00b1\u200919.1% vs. 61.8%\u2009\u00b1\u200917.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and 24\u2009months (68.7%\u2009\u00b1\u200921.9% vs. 60.4%\u2009\u00b1\u200919.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040). The hypomethylated group maintained a stable weight loss plateau between 12 and 24\u2009months. Hypomethylation was associated with nominally higher\n                      <jats:italic>IL13<\/jats:italic>\n                      and\n                      <jats:italic>PRDM16<\/jats:italic>\n                      mRNA in adipose tissue (exploratory; uncorrected\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>VTRNA2\u20101<\/jats:italic>\n                      methylation status is associated with predictable variations and offers potential for preoperative risk stratification and personalized therapeutic strategies in managing severe obesity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70268","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:27:43Z","timestamp":1785457663000},"page":"1785-1795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic Signature of the Metastable Epiallele\n                    <i>VTRNA2\u20101<\/i>\n                    : Adipose Dysfunction and Suboptimal Bariatric Outcomes"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1715-8598","authenticated-orcid":false,"given":"Yi\u2010Chun","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Jung","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Lung","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"},{"name":"Division of Cardiology New Taipei Municipal TuCheng Hospital  New Taipei City Taiwan"},{"name":"College of Management Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng\u2010Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yun","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4549-1995","authenticated-orcid":false,"given":"Jih\u2010Kai","family":"Yeh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Yuan","family":"Chia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Lang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Medical Research Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Chang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u2010Sen","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horng\u2010Dar","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Life Science National Tsing Hua University  HsinChu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Neu","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Yung","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital Linkou Medical Center  Taoyuan City Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan City Taiwan"},{"name":"Institute of Cellular and System Medicine National Health Research Institutes  Zhunan Taiwan"},{"name":"Department of Medical Science National Tsing Hua University  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00355-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02403-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13203"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2019.1595297"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011768"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.228"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2026580118"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03556-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084251"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701234"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209906"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001416"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.125.322196"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22064"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2021.04.020"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-021-08329-w"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173809"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-024-01673-3"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065672"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201023\u20100180"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1458848"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.70268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:48:23Z","timestamp":1787755703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.70268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/oby.70268"],"URL":"https:\/\/doi.org\/10.1002\/oby.70268","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}