{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:20:53Z","timestamp":1787757653948,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017958","name":"Health Commission of Hubei Province","doi-asserted-by":"publisher","award":["WJ2025M174"],"award-info":[{"award-number":["WJ2025M174"]}],"id":[{"id":"10.13039\/100017958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to explore\u00a0personalized weight\u2010loss targets for metabolic syndrome (MetS) reversal by introducing the BMI\u2010normalization achievement rate (BMI\u2010NAR), a novel baseline\u2010BMI\u2010scaled metric.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a longitudinal cohort of 7340 adults with overweight\/obesity and\u00a0MetS from the ChinaHEART project, BMI\u2010NAR was defined as the percentage of progress toward a normal BMI (&lt;\u200924\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Logistic regression and restricted cubic splines assessed the dose\u2013response relationship between BMI\u2010NAR and MetS reversal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Each 50% increase in BMI\u2010NAR was significantly associated with MetS reversal (overall: OR\u2009=\u20091.10, 95% CI: 1.07\u20131.12; overweight: OR\u2009=\u20091.08, 95% CI: 1.06\u20131.11; obesity: OR\u2009=\u20092.36, 95% CI: 2.00\u20132.80). The probability of reversal increased steeply beyond exploratory minimum effective thresholds (37% BMI\u2010NAR for overall; 53% for overweight; 22% for obesity), with benefits observed up to ~165% in the total population, beyond which data were sparse. No clear upper plateau was identified in populations with overweight and obesity. These exploratory thresholds translate into personalized weight\u2010loss targets: a minimum reduction of 2%\u20138% for typical overweight (baseline BMI 25\u201327.99\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and 3%\u20139% for obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MetS reversal does not require full BMI normalization. BMI\u2010NAR provides a hypothesis\u2010generating, quantifiable framework for exploring personalized minimum effective weight\u2010loss goals in this high\u2010risk population. However, external validation is required before clinical application.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/oby70269-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70269","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:19:34Z","timestamp":1785550774000},"page":"1718-1731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized Weight\u2010Loss Targets for Metabolic Syndrome Reversal: A\n                    <scp>BMI<\/scp>\n                    \u2010Normalization Achievement Rate\u2010Based Cohort Study"],"prefix":"10.1002","volume":"34","author":[{"given":"Junfeng","family":"Qi","sequence":"first","affiliation":[{"name":"Institute of Chronic and Non\u2010Communicable Disease Control and Prevention, Hubei Provincial Center for Disease Control and Prevention  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longzhu","family":"Xiong","sequence":"additional","affiliation":[{"name":"Environmental Toxicology Laboratory, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health Wuhan University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuansha","family":"Wu","sequence":"additional","affiliation":[{"name":"Environmental Toxicology Laboratory, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of 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