{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:59:00Z","timestamp":1790413140348,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK133465"],"award-info":[{"award-number":["R01DK133465"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study\u00a0assessed glucagon\u2010like peptide\u20101 receptor agonist (GLP\u20101 RA) effectiveness and safety in adults with weight recurrence after metabolic and bariatric surgery (MBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective new\u2010user cohort study using OneFlorida+ Data Trust (2015\u20102024)\u00a0among adults with \u2265\u200910% post\u2010MBS weight recurrence. GLP\u20101 RA users were matched to non\u2010users on BMI and timing of clinical encounter; the index date was defined as GLP\u20101 RA initiation for users and a matched reference date for non\u2010users. Inverse probability of treatment weighting was applied to further control for confounding. Effectiveness was measured as percentage of recurrent weight lost [(index weight\u2009\u2212\u2009follow\u2010up weight) \u00f7 (index weight\u2009\u2212\u2009nadir weight)\u2009\u00d7\u2009100] at 6 and 12\u2009months; safety outcomes included gastrointestinal and post\u2010MBS adverse events. Effectiveness was compared using\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, and safety was assessed using Cox proportional hazards models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among patients with \u2265\u200910% weight recurrence, 68 GLP\u20101 RA users and 131 non\u2010users were included at 6\u2009months, and 72 users and 139 non\u2010users were included at 12\u2009months. GLP\u20101 RA users lost significantly more recurrent weight at 6\u2009months (9.6% vs. 4.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and 12\u2009months (14.8% vs. 8.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), with no increased risk of adverse events at either time point.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among adults with post\u2010MBS weight recurrence, GLP\u20101 RAs were associated with greater weight loss without increased adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70280","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:51:51Z","timestamp":1787719911000},"page":"1860-1868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Effectiveness and Safety of\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists Among Patients With Weight Recurrence After Bariatric Surgery"],"prefix":"10.1002","volume":"34","author":[{"given":"Tarik","family":"Yuce","sequence":"first","affiliation":[{"name":"Surgical Outcomes and Quality Improvement Center (SOQIC), Department of Surgery Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-0637","authenticated-orcid":false,"given":"Rotana M.","family":"Radwan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy College of Pharmacy, University of Florida  Gainesville Florida USA"},{"name":"Department of Pharmacy Practice College of Pharmacy, Purdue University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao An","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy College of Pharmacy, University of Florida  Gainesville Florida USA"},{"name":"Department of Biostatistics &amp; Health Data Science Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Holler","sequence":"additional","affiliation":[{"name":"Surgical Outcomes and Quality Improvement Center (SOQIC), Department of Surgery Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Dai","sequence":"additional","affiliation":[{"name":"Department 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