{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:59:03Z","timestamp":1790413143374,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK51684"],"award-info":[{"award-number":["R01 DK51684"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK 49779"],"award-info":[{"award-number":["R01 DK 49779"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["M01\u2010RR00032"],"award-info":[{"award-number":["M01\u2010RR00032"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010DK56336"],"award-info":[{"award-number":["P30\u2010DK56336"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to quantify changes in predicted 10\u2010year risk for major adverse cardiovascular events (MACE) and type 2 diabetes (T2D) across weight loss, post\u2013weight loss (Post\u2010WL), and 1\u2010year follow\u2010up and to determine whether trajectories varied by exercise modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sedentary women with overweight (21\u201349\u2009years) were randomized to Diet+Aerobic, Diet+Resistance, or Diet\u2010only and completed an 800\u2009kcal\/day diet until BMI &lt;\u200925\u2009kg\u2009m\n                      <jats:sup>\u22122<\/jats:sup>\n                      . Predicted 10\u2010year MACE and T2D risks were calculated using cardiometabolic disease staging equations. Longitudinal changes and adherence effects were analyzed using fractional logit models fit with generalized estimating equations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 221 women (115 African American), mean BMI decreased from 28.3 to 23.9 kg m\n                      <jats:sup>\u22122<\/jats:sup>\n                      , with regain to 25.8 at 1 year. MACE risk decreased from Baseline to Post\u2010WL and rebounded from Post\u2010WL to 1 year in all groups (all\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001). Diet\u2010only achieved greater MACE reduction than Diet+Resistance (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.022). T2D risk decreased in all groups (all\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001) but rebounded in Diet+Aerobic and Diet\u2010only. The Diet+Resistance group maintained a significant net reduction at 1 year (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.003). Follow\u2010up exercise adherence was associated with lower T2D risk rebound (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.024).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Weight loss reduced MACE and T2D risks, but both rebounded with weight regain. Resistance exercise may be beneficial in weight loss interventions to prevent progression to T2D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT00067873\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70291","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:26:17Z","timestamp":1787541977000},"page":"1869-1879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Weight Loss Improves Predicted 10\u2010Year\n                    <scp>MACE<\/scp>\n                    and Type 2 Diabetes Risk, but Benefits Partially Rebound at 1 Year"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-9804","authenticated-orcid":false,"given":"Abdelrahman M.","family":"Elshakankiry","sequence":"first","affiliation":[{"name":"Department of Nutrition Sciences, School of Health Professions University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-242X","authenticated-orcid":false,"given":"Gary R.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences, School of Health Professions University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4560-0013","authenticated-orcid":false,"given":"C\u00e1tia","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences, School of Health Professions University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9191-3774","authenticated-orcid":false,"given":"Gordon","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Human Studies University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0822-0860","authenticated-orcid":false,"given":"W. 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