{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:06:28Z","timestamp":1789002388571,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n This study aimed to\u00a0evaluate the impact of three lifestyle interventions on perceived physical fatigability.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Concurrent with a dietary weight loss program (caloric deficit ~400\u2009kcal\/day, weekly dietitian support), older adults with obesity (\n N<\/jats:italic>\n \u2009=\u2009183) were randomized to three groups: aerobic exercise (150\u2013200\u2009min\/week of moderate\u2010intensity treadmill walking;\n n<\/jats:italic>\n \u2009=\u200960), daylong movement (improving daily activity distribution, progressively increase steps\/day;\n n<\/jats:italic>\n \u2009=\u200963), or combination (aerobic and daylong movement interventions;\n n<\/jats:italic>\n \u2009=\u200960). Perceived physical fatigability (Pittsburgh Fatigability Scale [PFS] Physical score, range 0\u201350, and Rating of Perceived Exertion [RPE] after a 5\u2010min 0% grade treadmill walk, range 6\u201320; higher\u2009=\u2009greater fatigability) was measured at baseline, 6\u2009months (post\u2010intensive intervention), and 18\u2009months (end of maintenance period).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants (69.6\u2009\u00b1\u20094.3\u2009years, 77% female, 74% White, 35.6\u2009\u00b1\u20093.8\u2009kg\/m\n 2<\/jats:sup>\n BMI) had a PFS Physical score 20.6\u2009\u00b1\u20097.6 and RPE Fatigability 9.6\u2009\u00b1\u20091.9 at baseline. Clinically relevant improvements were observed in PFS score from baseline to 6\u2009months (\u22124.4 points,\n p<\/jats:italic>\n \u2009=\u20090.002) and were largely maintained at 18\u2009months (\u22123.0 points,\n p<\/jats:italic>\n \u2009=\u20090.03) after adjustment for baseline age, sex, education, intervention group, and time\u2009\u00d7\u2009intervention group (\n p<\/jats:italic>\n \u2009=\u20090.83). RPE Fatigability did not improve (\n p<\/jats:italic>\n \u2009>\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Multiple physical activity strategies in conjunction with weight loss improved perceived physical fatigability over time among older adults with obesity.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n identifier: NCT02923674\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/oby.70298","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:13:55Z","timestamp":1788999235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Weight Loss and Physical Activity Reduces Perceived Physical Fatigability Among Older Adults With Obesity"],"prefix":"10.1002","author":[{"given":"Reagan E.","family":"Garcia","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh School of Public Health Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Fanning","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Sciences Wake Forest University Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9442-8515","authenticated-orcid":false,"given":"Chaeryon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"},{"name":"Department of Biostatistics and Health Data Science University of Pittsburgh School of Public Health Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4096-917X","authenticated-orcid":false,"given":"Bonny","family":"Rockette\u2010Wagner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh School of Public Health Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-9430","authenticated-orcid":false,"given":"Christopher E.","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Health and Human Development University of Pittsburgh School of Education Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Nicklas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest University School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-0162","authenticated-orcid":false,"given":"Nancy W.","family":"Glynn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh School of Public Health Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"12","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.50241","article-title":"Global Healthspan\u2010Lifespan Gaps Among 183 World Health Organization Member States","volume":"7","author":"Garmany A.","year":"2024","journal-title":"JAMA Network Open"},{"issue":"5","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1532-5415.2010.02811.x","article-title":"Bedside\u2010to\u2010Bench Conference: Research Agenda for Idiopathic Fatigue and Aging","volume":"58","author":"Alexander N. 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