{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:52:07Z","timestamp":1791348727722,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301936"],"award-info":[{"award-number":["82301936"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402162"],"award-info":[{"award-number":["82402162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The Developmental Origins of Health and Disease hypothesis posits that paternal environmental exposures program offspring metabolic health via sperm epigenetic factors, particularly tRNA\u2010derived small RNAs (tsRNAs). Cadmium (Cd) is a ubiquitous environmental pollutant known to impair reproductive health, but epigenetic links to offspring metabolic disorders are unclear. Using paternal Cd exposure, we elucidate sperm tsRNA pathogenic mechanisms in intergenerational inheritance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We validated candidate tsRNA functions via zygotic microinjection of agomirs in mice and transfection in AML12 cells in vitro. For mechanistic insights, we conducted blastocyst low\u2010input RNA sequencing, liver transcriptomics, and in\u00a0vitro assays (luciferase, Western blot, immunofluorescence).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Transfection of Cd\u2010upregulated sperm tsRNAs (tRF\u2010Leu\u2010CAA, tRF\u2010Ala\u2010AGC) inhibited PPAR signaling in AML12 cells and caused lipid disorders. In\u00a0vivo, microinjection recapitulated paternal Cd effects: impaired embryogenesis and adult metabolic syndromes (weight gain, hyperlipidemia, hepatic steatosis). Mechanistically, tsRNAs suppressed Wnt and PPAR pathways from the two\u2010cell stage, with LEF1\/WNT5A as direct Wnt targets; this suppression persisted in adult liver.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We propose a two\u2010hit mechanism: first hit via early embryonic Wnt\/PPAR co\u2010suppression, second hit via sustained\u00a0inhibition into adulthood, driving metabolic dysregulation. Thus, tsRNAs are key epigenetic vectors linking paternal Cd exposure to offspring metabolic health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70303","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:47:19Z","timestamp":1791348439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>tsRNAs<\/scp>\n                    Mediate Intergenerational Inheritance by Concertedly Suppressing Wnt and\n                    <scp>PPAR<\/scp>\n                    Pathways"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9876-0850","authenticated-orcid":false,"given":"Jinzhao","family":"Zhou","sequence":"first","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"},{"name":"Institute of Reproductive Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei People's\u00a0Republic\u00a0of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Liu","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"},{"name":"Medical Genetics Center Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei People's\u00a0Republic\u00a0of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2254-1839","authenticated-orcid":false,"given":"Yayun","family":"Qin","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"},{"name":"Medical Genetics Center Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Yi","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"},{"name":"Medical Genetics Center Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"},{"name":"Medical Genetics Center Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hu","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"},{"name":"Medical Genetics Center Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-9037","authenticated-orcid":false,"given":"Jieping","family":"Song","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"},{"name":"Medical Genetics Center Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-823X","authenticated-orcid":false,"given":"Ling","family":"Zeng","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"},{"name":"Medical Genetics Center Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei People's\u00a0Republic\u00a0of\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"10132","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0140-6736(18)30312-X","article-title":"Origins of Lifetime Health Around the Time of Conception: Causes and Consequences","volume":"391","author":"Fleming T. P.","year":"2018","journal-title":"Lancet"},{"issue":"7911","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41586-022-04756-4","article-title":"Maternal Inheritance of Glucose Intolerance via Oocyte TET3 Insufficiency","volume":"605","author":"Chen B.","year":"2022","journal-title":"Nature"},{"issue":"17","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.scib.2022.07.030","article-title":"The Epigenetic Mechanisms Underlying Gamete Origin of Adult\u2010Onset Diseases","volume":"67","author":"Ding G.","year":"2022","journal-title":"Science Bulletin"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.cmet.2025.09.003","article-title":"Paternal Exercise Confers Endurance Capacity to Offspring Through Sperm microRNAs","volume":"37","author":"Yin X.","year":"2025","journal-title":"Cell Metabolism"},{"issue":"13","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202408912","article-title":"Vitamin C\u2010Dependent Intergenerational Inheritance of Enhanced Endurance Performance Following Maternal Exercise","volume":"12","author":"Shi H.","year":"2025","journal-title":"Advanced Science (Weinh)"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.stem.2025.09.009","article-title":"EZHIP Restricts Noncanonical PRC2 Binding and Regulates H3K27me3 Intergenerational Inheritance and Reprogramming","volume":"32","author":"Zeng Y.","year":"2025","journal-title":"Cell Stem Cell"},{"issue":"8","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41574-019-0226-2","article-title":"Sperm RNA Code Programmes the Metabolic Health of Offspring","volume":"15","author":"Zhang Y.","year":"2019","journal-title":"Nature Reviews. Endocrinology"},{"issue":"10","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.tibs.2021.05.001","article-title":"Origins and Evolving Functionalities of tRNA\u2010Derived Small RNAs","volume":"46","author":"Chen Q.","year":"2021","journal-title":"Trends in Biochemical Sciences"},{"issue":"7","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cell.2010.12.008","article-title":"Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals","volume":"143","author":"Carone B. R.","year":"2010","journal-title":"Cell"},{"issue":"6271","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.aad7977","article-title":"Sperm tsRNAs Contribute to Intergenerational Inheritance of an Acquired Metabolic Disorder","volume":"351","author":"Chen Q.","year":"2016","journal-title":"Science"},{"issue":"6271","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1126\/science.aad6780","article-title":"Biogenesis and Function of tRNA Fragments During Sperm Maturation and Fertilization in Mammals","volume":"351","author":"Sharma U.","year":"2016","journal-title":"Science"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1038\/ncomms6466","article-title":"Early Life Stress in Fathers Improves Behavioural Flexibility in Their Offspring","volume":"5","author":"Gapp K.","year":"2014","journal-title":"Nature Communications"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.aquatox.2015.10.020","article-title":"Reproductive Toxicity of Low Level Bisphenol A Exposures in a Two\u2010Generation Zebrafish Assay: Evidence of Male\u2010Specific Effects","volume":"169","author":"Chen J.","year":"2015","journal-title":"Aquatic Toxicology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tox.2018.10.007","article-title":"Reproductive and Developmental F1 Toxicity Following Exposure of Pubescent F0 Male Mice to Bisphenol A Alone and in a Combination With X\u2010Rays Irradiation","volume":"410","author":"Dobrzy\u0144ska M. M.","year":"2018","journal-title":"Toxicology"},{"issue":"5","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1095\/biolreprod.112.106104","article-title":"Transgenerational Effects of di\u2010(2\u2010Ethylhexyl) Phthalate on Testicular Germ Cell Associations and Spermatogonial Stem Cells in Mice","volume":"88","author":"Doyle T. J.","year":"2013","journal-title":"Biology of Reproduction"},{"issue":"3","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.reprotox.2008.02.001","article-title":"Cadmium: Toxic Effects on the Reproductive System and the Embryo","volume":"25","author":"Thompson J.","year":"2008","journal-title":"Reproductive Toxicology"},{"issue":"1","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41419-020-2246-1","article-title":"Cross\u2010Talk Between Autophagy and Apoptosis Regulates Testicular Injury\/Recovery Induced by Cadmium via PI3K With mTOR\u2010Independent Pathway","volume":"11","author":"Wang M.","year":"2020","journal-title":"Cell Death and Disease"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.freeradbiomed.2021.09.028","article-title":"Cadmium Attenuates Testosterone Synthesis by Promoting Ferroptosis and Blocking Autophagosome\u2010Lysosome Fusion","volume":"176","author":"Zeng L.","year":"2021","journal-title":"Free Radical Biology and Medicine"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157500","article-title":"Cadmium Exposure Induces Pyroptosis in Testicular Tissue by Increasing Oxidative Stress and Activating the AIM2 Inflammasome Pathway","volume":"847","author":"Zhou J.","year":"2022","journal-title":"Science of the Total Environment"},{"issue":"3","key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1289\/EHP360","article-title":"Sex\u2010Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice","volume":"125","author":"Ba Q.","year":"2017","journal-title":"Environmental Health Perspectives"},{"issue":"4","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1289\/EHP481","article-title":"Effects of Periconception Cadmium and Mercury co\u2010Administration to Mice on Indices of Chronic Diseases in Male Offspring at Maturity","volume":"125","author":"Camsari C.","year":"2017","journal-title":"Environmental Health Perspectives"},{"key":"e_1_2_11_23_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125776","article-title":"Paternal Cadmium Exposure Increases the Susceptibility to Diet\u2010Induced Testicular Injury and Spermatogenic Disorders in Mouse Offspring","volume":"246","author":"Nan Y.","year":"2020","journal-title":"Chemosphere"},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139592","article-title":"Paternal Cadmium Exposure Induces Glucolipid Metabolic Reprogramming in Offspring Mice via PPAR Signaling Pathway","volume":"339","author":"Zeng L.","year":"2023","journal-title":"Chemosphere"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113947","article-title":"Paternal Cadmium Exposure Affects Testosterone Synthesis by Reducing the Testicular Cholesterol Pool in Offspring Mice","volume":"242","author":"Zhou J.","year":"2022","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115280","article-title":"Paternal Cadmium Exposure Affects Estradiol Synthesis by Impairing Intracellular Cholesterol Homeostasis and Mitochondrial Function in Offspring Female Mice","volume":"263","author":"Zhang Y.","year":"2023","journal-title":"Ecotoxicology and Environmental Safety"},{"issue":"10","key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-021-00378-6","article-title":"Cancer Metabolism: Looking Forward","volume":"21","author":"Mart\u00ednez\u2010Reyes I.","year":"2021","journal-title":"Nature Reviews. Cancer"},{"issue":"1","key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2020.10.011","article-title":"The Intersection of Epigenetics and Metabolism in Trained Immunity","volume":"54","author":"Fanucchi S.","year":"2021","journal-title":"Immunity"},{"key":"e_1_2_11_29_1","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/684159","article-title":"Functional Role of\u00a0PPARs in Ruminants: Potential Targets for Fine\u2010Tuning Metabolism During Growth and Lactation","volume":"2013","author":"Bionaz M.","year":"2013","journal-title":"PPAR Research"},{"issue":"3","key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.3168\/jds.2017-13543","article-title":"Peroxisome Proliferator\u2010Activated Receptor Delta Regulates Lipid Droplet Formation and Transport in Goat Mammary Epithelial Cells","volume":"101","author":"Shi H. B.","year":"2018","journal-title":"Journal of Dairy Science"},{"issue":"11","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/cr.2012.141","article-title":"A Novel Class of tRNA\u2010Derived Small RNAs Extremely Enriched in Mature Mouse Sperm","volume":"22","author":"Peng H.","year":"2012","journal-title":"Cell Research"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.791784","article-title":"Differential Expression Profiles and Potential Intergenerational Functions of tRNA\u2010Derived Small RNAs in Mice After Cadmium Exposure","volume":"9","author":"Zeng L.","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"4","key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: A Fast Spliced Aligner With Low Memory Requirements","volume":"12","author":"Kim D.","year":"2015","journal-title":"Nature Methods"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: Accurate Transcript Quantification From RNA\u2010Seq Data With or Without a Reference Genome","volume":"12","author":"Li B.","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"12","key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated Estimation of Fold Change and Dispersion for RNA\u2010Seq Data With DESeq2","volume":"15","author":"Love M. I.","year":"2014","journal-title":"Genome Biology"},{"issue":"7","key":"e_1_2_11_36_1","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma Powers Differential Expression Analyses for RNA\u2010Sequencing and Microarray Studies","volume":"43","author":"Ritchie M. E.","year":"2015","journal-title":"Nucleic Acids Research"},{"issue":"3","key":"e_1_2_11_37_1","article-title":"clusterProfiler 4.0: A Universal Enrichment Tool for Interpreting Omics Data","volume":"2","author":"Wu T.","year":"2021","journal-title":"Innovation (Camb)"},{"issue":"2","key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/C5MB00663E","article-title":"ReactomePA: An R\/Bioconductor Package for Reactome Pathway Analysis and Visualization","volume":"12","author":"Yu G.","year":"2016","journal-title":"Molecular BioSystems"},{"issue":"14","key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.scib.2025.05.003","article-title":"Persistent Wnt Signaling Affects IVF Embryo Implantation and Offspring Metabolism","volume":"70","author":"Jia Y.","year":"2025","journal-title":"Science Bulletin (Beijing)"},{"issue":"1","key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/joim.13263","article-title":"Developmental Regulation of Barrier\u2010 and Non\u2010Barrier Blood Vessels in the CNS","volume":"292","author":"Ben\u2010Zvi A.","year":"2022","journal-title":"Journal of Internal Medicine"},{"issue":"2","key":"e_1_2_11_41_1","first-page":"713","article-title":"Multi\u2010Layered Prevention and Treatment of Chronic Inflammation, Organ Fibrosis and Cancer Associated With Canonical WNT\/\u03b2\u2010Catenin Signaling Activation (Review)","volume":"42","author":"Katoh M.","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"issue":"4","key":"e_1_2_11_42_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041854","article-title":"Wnt\/\u03b2\u2010Catenin Pathway\u2010Mediated PPAR\u03b4 Expression During Embryonic Development Differentiation and Disease","volume":"22","author":"Sidrat T.","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1479164117738442","article-title":"Interrelationship of Canonical and Non\u2010Canonical Wnt Signalling Pathways in Chronic Metabolic Diseases","volume":"15","author":"Ackers I.","year":"2018","journal-title":"Diabetes and Vascular Disease Research"},{"issue":"1","key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"D30","DOI":"10.1093\/nar\/gkae978","article-title":"Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025","volume":"53","author":"CNCB\u2010NGDC Members and Partners","year":"2025","journal-title":"Nucleic Acids Research"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.70303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:47:29Z","timestamp":1791348449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.70303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":43,"alternative-id":["10.1002\/oby.70303"],"URL":"https:\/\/doi.org\/10.1002\/oby.70303","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2026-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"oby.70303"}}