{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:52:51Z","timestamp":1791341571206,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/17782\u20103"],"award-info":[{"award-number":["2023\/17782\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["1\u201025\u2010PDF\u2010103"],"award-info":[{"award-number":["1\u201025\u2010PDF\u2010103"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of breaking up sedentary behavior (SB) on daily movement behavior and energy balance in adults with overweight\/obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty participants (16F\/14M; 34.2\u2009\u00b1\u20097.3\u2009years; 29.5\u2009\u00b1\u20093.2\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) were randomized to either BREAK (multiple 5\u2010min brisk walking bouts) or a duration\u2010matched intervention, ONE (45\u2010min brisk walking), performed 5\u2009days\/week for 6\u2009weeks. At pre\u2010 and post\u2010intervention, daily SB and physical activity (PA; accelerometry), body composition (doubly labeled water [DLW]), total daily energy expenditure (TDEE; DLW), appetite, and fasting leptin were measured. Linear mixed\u2010effects models tested time effects and group\u2010by\u2010time interactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Only BREAK reduced prolonged SB (interaction:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043). Both groups shifted SB\u2010PA composition toward greater moderate\u2010to\u2010vigorous PA, with proportional reductions in SB and light PA (time: all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.011). These changes in PA level were\u00a0associated with increased TDEE (time:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040). ONE showed small increases in body and fat mass compared with BREAK (interaction: both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.061). No differences were noted in metabolizable energy intake, appetite, or leptin levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Spreading short PA bouts throughout the day increases moderate\u2010to\u2010vigorous PA and TDEE to the same extent as a traditional continuous PA bout. Future studies should investigate whether the modest body composition changes observed across interventions are driven by distinct behavioral\/physiological compensations influenced by the daily pattern of PA\/SB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT02998892\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70310","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:46:18Z","timestamp":1791341178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frequent Versus Single Active Bouts Differentially Affect Movement Behavior and Energy Balance in Adults With Overweight\/Obesity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9177-7410","authenticated-orcid":false,"given":"Heloisa C.","family":"Santo Andre","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism and Diabetes, Anschutz Health and Wellness Center, Department of Medicine, School of Medicine University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Faculty of Applied Sciences State University of Campinas  Limeira S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Le Roux","sequence":"additional","affiliation":[{"name":"Institut Pluridisciplinaire Hubert Curien, UMR7178 Centre National de la Recherche Scientifique, Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"De Jong","sequence":"additional","affiliation":[{"name":"Division of 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