{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:44:12Z","timestamp":1792215852817,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F32 AG079581"],"award-info":[{"award-number":["F32 AG079581"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25CDA1446479"],"award-info":[{"award-number":["25CDA1446479"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n Heat\u2010related mortality is greater in middle\u2010aged and older women, compared with age\u2010matched men, and in those with obesity, although the causes are unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thermoregulatory and cardiovascular responses were assessed in (\n n<\/jats:italic>\n \u2009=\u200910 per group) young women (21\u2009\u00b1\u20092\u2009years), middle\u2010aged women without obesity (\u2212OB; 55\u2009\u00b1\u20096\u2009years), and middle\u2010aged women with obesity (+OB; 55\u2009\u00b1\u20094\u2009years) during whole\u2010body heat stress until a change in core temperature (\u0394\n T<\/jats:italic>\n c<\/jats:sub>\n )\u2009=\u20091\u00b0C. Cutaneous vasodilation (laser\u2010Doppler flowmetry) and whole\u2010body sweat rate (sweat loss\/body surface area\/time) were measured as indices of thermoregulatory function. Heart rate and blood pressure were measured, and rate pressure product (RPP\u2009=\u2009heart rate \u00d7 systolic blood pressure) was calculated as an index of cardiovascular strain.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The magnitude of the peak cutaneous vasodilation response was not different among the groups (\n p<\/jats:italic>\n \u2009\u2265\u20090.21), but thermosensitivity was higher in Young compared with +OB and \u2212OB (\n p<\/jats:italic>\n \u2009\u2264\u20090.03). Although there were no baseline differences in RPP (\n p<\/jats:italic>\n \u2009\u2265\u20090.67), end\u2010heating RPP was higher in +OB compared with \u2212OB and Young (\n p<\/jats:italic>\n \u2009\u2264\u20090.008). Further, body fat percentage was related to peak RPP (\n p<\/jats:italic>\n \u2009=\u20090.03,\n R<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.24) in middle\u2010aged women.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Increased adiposity may contribute to greater cardiovascular risk during extreme heat exposure in middle\u2010aged women.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/oby.70314","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:19:52Z","timestamp":1792214392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Obesity Increases Cardiovascular Strain During Passive Whole\u2010Body Heat Stress in Middle\u2010Aged Women"],"prefix":"10.1002","author":[{"given":"Georgia R.","family":"Davila","sequence":"first","affiliation":[{"name":"Department of Kinesiology University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3306-0763","authenticated-orcid":false,"given":"Sandra N.","family":"Fredericks","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9304-5319","authenticated-orcid":false,"given":"William E.","family":"Jennings","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8033-6734","authenticated-orcid":false,"given":"Emily A.","family":"Haskell","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8265-4360","authenticated-orcid":false,"given":"Jamie A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-2143","authenticated-orcid":false,"given":"S. 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