{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:32:22Z","timestamp":1780374742312,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Limited progress has occurred in treating operable human papillomavirus (HPV)\u2010negative head and neck squamous cell carcinoma (HNSCC). Accessing timely care remains challenging in public health care systems, potentially resulting in disease progression before treatment initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective cohort of patients receiving neoadjuvant capecitabine (NC) was compared to stage\u2010matched patients undergoing standard of care (SC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>This study was performed at 2 academic centers in Montreal, Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To ascertain the effect of 2 cycles of NC in operable HPV\u2010negative HNSCC patients on clinical\u2010to\u2010pathologic stage migration. Comparison to an SC group was performed to site and TNM stage matched patients. Pathologic treatment response was measured using the modified Ryan score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We compared 16 NC patients (11 oral cavity, 3 skin, 2 larynx) with 32 SC patients. Ten NC patients exhibited a pathologic response (1 complete, 3 major, 6 minor). Clinical\u2010to\u2010pathologic stage migration differed significantly between NC and SC groups: downstage (6 vs 1), upstage (3 vs 14), no change (7 vs 17, <jats:italic>P<\/jats:italic>\u2009=\u2009.0047). There was no severe treatment toxicity related to capecitabine. All patients in the NC group underwent surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NC followed by surgery demonstrates measurable pathologic response in HPV\u2010negative HNSCC, suggesting potential utility in resource\u2010limited health care settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1003","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T07:14:09Z","timestamp":1727594049000},"page":"1773-1779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neoadjuvant Capecitabine in Operable HPV\u2010Negative Head and Neck Cancer: Fortuitous Findings in a Resource Constrained Setting"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8880-805X","authenticated-orcid":false,"given":"Marco A.","family":"Mascarella","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Canada"},{"name":"Centre for Clinical Epidemiology, Lady Davis Institute of the Jewish General Hospital Montreal Canada"},{"name":"McGill Centre for Translational Research in Cancer, McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Mlynarek","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Hier","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derin","family":"Caglar","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Florianova","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Philippe","family":"Pusztaszeri","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Sultanem","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology Jewish General Hospital Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Bouganim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khashayar","family":"Esfahani","sequence":"additional","affiliation":[{"name":"McGill Centre for Translational Research in Cancer, McGill University Montreal Canada"},{"name":"Division of Medical Oncology, Department of Medicine McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.191292"},{"key":"e_1_2_8_3_1","unstructured":"National Cancer Institute SEER. 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