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Continuous positive airway pressure (CPAP) served as a control. Outcomes studied included pre\u2010 and postintervention obstructive apnea\u2010hypopnea index. Studies included randomized controlled trials and case\u2010control trials. A total of 2161 records were identified, and 59 studies were included in the analysis. Data was extracted following Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses guidelines and pooled using a random\u2010effects model. The primary study outcome established prior to data collection was a change in the apnea\u2010hypopnea index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A meta\u2010analysis of MDO performed in infants for OSA demonstrated an overall pooled mean difference (pre\u2010apnea\u2010hypopnea index minus post\u2010apnea hypopnea index) of 30.1 (95% confidence interval: 22.9, 37.4; 10 studies, 373 patients). No other data was pooled for analysis due to study heterogeneity. All CPAP studies showed apnea resolution. Tailored therapies including supraglottoplasty and tongue\u2010lip adhesion reduced but did not resolve apneic events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current investigations of the evaluation and treatment of infant OSA are limited by heterogeneity in reporting and study. 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