{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:16Z","timestamp":1761007456744,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Examine the association between age and treatment outcomes in conditions causing single\u2010 versus multilevel airway restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Multi\u2010institutional retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary laryngology centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants included younger (18\u201064 years) and geriatric (\u226565 years) adults with posterior glottic stenosis (PGS), multilevel airway stenosis (MLAS), and bilateral vocal fold paralysis (BVFP). Subgroup demographics, comorbidities, type, and etiology of airway compromise were described. Associations between age and primary outcome variables (i.e., tracheostomy and decannulation rates, number of surgeries performed, time between surgeries, and change in quality\u2010of\u2010life patient\u2010reported outcome measures [PROMs]) were evaluated. Statistical analyses included independent <jats:italic>t<\/jats:italic> tests, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>, Fisher's exact, or Mann\u2010Whitney tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 158 patients [96 younger (30 PGS, 29 MLAS, 37 BVFP) and 62 geriatric (24 PGS, 9 MLAS, 29 BVFP)], age differences were not significant for gender (<jats:italic>P<\/jats:italic>\u2009=\u2009.990), tracheostomy placement (70% vs 66%, <jats:italic>P<\/jats:italic>\u2009=\u2009.629), or decannulation success (40% vs 24%, <jats:italic>P<\/jats:italic>\u2009=\u2009.091) in younger versus geriatric groups, respectively. In younger patients, MLAS was more common (30.2% vs 14.5%, <jats:italic>P<\/jats:italic>\u2009=\u2009.024), and BVFP patients were more likely to decannulate (50% vs 12%, <jats:italic>P<\/jats:italic>\u2009=\u2009.017). Geriatric patients were more likely to have a history of prior radiation (26% vs 10%, <jats:italic>P<\/jats:italic>\u2009=\u2009.016), stenosis due to malignancy (23% vs 9%, <jats:italic>P<\/jats:italic>\u2009=\u2009.022), and fewer overall surgeries (median 1 vs 3, <jats:italic>P<\/jats:italic>\u2009=\u2009.003). Median PROMs were comparable between age subgroups (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Younger adults underwent more surgeries, but overall comorbidities, tracheostomy decannulation rates, and PROMs were comparable between groups. Age does not negatively impact treatment outcomes and should not be a deterrent in treatment decision\u2010making.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1026","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T02:20:11Z","timestamp":1730859611000},"page":"199-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Age in Single\u2010Level Versus Multilevel Airway Compromise: A Multi\u2010Institutional Review"],"prefix":"10.1002","volume":"172","author":[{"given":"Chanticha","family":"Laohakittikul","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inderpreet Kaur","family":"Khalsa","sequence":"additional","affiliation":[{"name":"University of California\u2013San Francisco School of Medicine San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shambavi J.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6460-5285","authenticated-orcid":false,"given":"Steven D.","family":"Stockton","sequence":"additional","affiliation":[{"name":"Stockton Scientific Services Glastonbury Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndsay L.","family":"Madden","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Cates","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2010Davis School of Medicine Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VyVy N.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2010San Francisco Voice and Swallowing Center San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/hn.1999.v121.a98733"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70248-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27594"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415608867"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2014.12.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30269"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198305000-00009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24956"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003886"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061780"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2020.00213"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.210150"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40137-016-0140-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0329-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-1866"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2018.11.020"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816675323"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.100780"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2019.04.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.08.026"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181ae575a"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-018-1375-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3750-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0578"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10324"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107680109400508"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","unstructured":"BenningerMS SyamalM GauVL BrysonPC HrelecC. 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