{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:17:51Z","timestamp":1782785871260,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of 2 drug combinations on tinnitus severity and associated stress, depression, sleep, and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled clinical trial conducted between 2019 and 2023 for an 8\u2010week duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single institution tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study recruited adult patients with moderate to severe tinnitus for 6 months or more. In total, 81 patients were assessed for eligibility, 78 were enrolled and randomized, and 67 were included in the per\u2010protocol analysis. Patients were randomized into 3 groups (1:1:1). Group NT received nortriptyline\u2010topiramate, group VP received verapamil\u2010paroxetine, and group P received placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 19 patients in group NT, 22 in group VP, and 26 patients in group P were included in the per\u2010protocol analysis. In group NT, the Tinnitus Functional Index (TFI) score decreased from 58.4\u2009\u00b1\u200913.9 (baseline) to 46.3\u2009\u00b1\u200917.5 (end\u2010of\u2010trial) (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Similarly, in group VP, the TFI score decreased from 54.6\u2009\u00b1\u200917.5 to 42.2\u2009\u00b1\u200916.1 (<jats:italic>P<\/jats:italic>\u2009=\u2009.004). However, group P did not demonstrate any significant decrease in the TFI score from 51.2\u2009\u00b1\u200918.6 to 45.2\u2009\u00b1\u200920.1 (<jats:italic>P<\/jats:italic>\u2009=\u2009.086). The between\u2010arm analysis did not yield any statistical significance decrease in the TFI score (analysis of variance, <jats:italic>P<\/jats:italic>\u2009=\u2009.265).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both combinations of drugs were promising in improving tinnitus severity. However, larger\u2010scale trials with longer follow\u2010up periods are warranted to validate our findings between groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1063","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T05:13:53Z","timestamp":1732598033000},"page":"1348-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Nortriptyline\u2010Topiramate and Verapamil\u2010Paroxetine in Tinnitus Management: A Randomized Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-698X","authenticated-orcid":false,"given":"Mehdi","family":"Abouzari","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Tawk","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva D.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison W.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Djalilian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"},{"name":"Department of Biomedical Engineering University of California Irvine California USA"},{"name":"Department of Neurosurgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60142-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814545325"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.0697"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e31827d113a"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2527-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814566179"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2009.11.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728210903206975"},{"key":"e_1_2_9_10_1","unstructured":"AbouzariM DjalilianHR. 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