{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:18:14Z","timestamp":1780467494147,"version":"3.54.1"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite certain studies indicating hearing impairments in individuals with polycystic ovary syndrome (PCOS), the correlation between PCOS and sensorineural hearing loss (SNHL) remains inconclusive. This study aimed to investigate the association between PCOS and SNHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>A systematic literature search was conducted using PubMed, MEDLINE, EMBASE, and the Cochrane Library from inception to June 24, 2024.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>This meta\u2010analysis included cross\u2010sectional, case\u2010control, or cohort studies examining the association between PCOS and SNHL without language or regional restrictions. Case reports, case series, animal studies, and in vitro studies were excluded. We adhered to Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses guidelines and utilized the Newcastle\u2010Ottawa Scale to assess the risk of bias in the included studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After performing the systematic review, we conducted a meta\u2010analysis that included 489 patients from 5 studies: 349 patients with PCOS and 140 age\u2010 and sex\u2010matched controls without PCOS. The meta\u2010analysis compared the mean differences in frequency\u2010specific pure\u2010tone thresholds between patients with PCOS and matched controls, providing 95% confidence intervals for these differences. Given the expected clinical heterogeneity, we employed the DerSimonian and Laird random\u2010effects model. Our results revealed significant hearing loss at specific frequencies (1000, 4000, 8000, 10,000, 12,000, 14,000, 16,000, 18,000, and 20,000\u2009Hz) in the PCOS group compared to the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Furthermore, the degree of hearing loss is greater at higher frequencies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis demonstrated an association between PCOS and SNHL, particularly at higher frequencies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1081","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T10:09:31Z","timestamp":1735121371000},"page":"1121-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Polycystic Ovary Syndrome With Sensorineural Hearing Loss: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"172","author":[{"given":"Tai\u2010Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Jou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Livia Shan\u2010Yu Wan Chair Professor of Obstetrics and Gynecology National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang\u2010Hsu","family":"Lien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine Chang Gung University Taoyuan 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