{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:11:32Z","timestamp":1778919092729,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy, safety, and durability of temperature\u2010controlled radiofrequency (TCRF) treatment of the nasal valve in patients with severe or extreme nasal airway obstruction (NAO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A long\u2010term, prospective, multicenter, single\u2010blind, randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Sixteen otolaryngologic clinics and academic centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients received TCRF treatment on the lateral nasal valve. All patients were followed through 3 years. Outcome measures included the Nasal Obstruction Symptom Evaluation (NOSE) Scale, Epworth Sleepiness Scale (ESS), and adverse events (AEs). Treatment responders were defined as a \u22651 reduction in severity class or \u226520% reduction in NOSE score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 108 patients who received TCRF treatment, 54 reached the 3\u2010year follow\u2010up timepoint. The baseline mean NOSE score was 76.3 (95% confidence interval [CI], 73.6 to 79.1). The 3\u2010year NOSE score treatment effect was \u221249.4 ([95% CI, \u221256.5 to \u221242.4]; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) a 64.7% improvement from baseline; 88.7% of patients were responders. Most patients reported significant improvements in sleep post\u2010treatment with a mean ESS score of 4.5 (95% CI, 3.4 to 5.7) at 3 years compared to 10.3 (95% CI, 9.2 to 11.4) at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with the TCRF device for nasal valve obstruction resulted in sustained improvements in nasal obstruction symptoms and sleep quality over a 3\u2010year period without any serious AEs. These findings support the long\u2010term benefits and sustained improvements in symptoms in patients with NAO.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1118","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:15:28Z","timestamp":1737094528000},"page":"1214-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Temperature\u2010Controlled Radiofrequency Treatment of the Nasal Valve in Patients With Nasal Obstruction: Long\u2010Term Outcomes"],"prefix":"10.1002","volume":"172","author":[{"given":"Joseph K.","family":"Han","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Eastern Virginia Medical School Norfolk Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon N.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"ENT and Allergy Associates of Florida Coral Springs Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad M.","family":"McDuffie","sequence":"additional","affiliation":[{"name":"ENT Associates of Texas McKinney Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Yen","sequence":"additional","affiliation":[{"name":"Specialty Physician Associates Bethlehem Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadim B.","family":"Bikhazi","sequence":"additional","affiliation":[{"name":"Ogden Clinic Ogden Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkata Vasu","family":"Kakarlapudi","sequence":"additional","affiliation":[{"name":"Advanced ENT and Allergy New Albany Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey L.","family":"Silvers","sequence":"additional","affiliation":[{"name":"Madison ENT &amp; Facial Plastic Surgery New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_482_23"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200307000-00004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.26574\/maedica.2022.17.4.921"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1740948"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.04.019"},{"key":"e_1_2_9_7_1","first-page":"15","article-title":"The role of the nasal valve in patients with obstructive sleep apnea syndrome","volume":"90","author":"Gelardi M","year":"2019","journal-title":"Acta Biomed"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1849-5594"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2018.05.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/wjo2.114"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2024.104338"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"202","article-title":"Utility of radiofrequency treatment of the internal nasal valve status post rhinoplasty: a salvage technique","volume":"167","author":"Sims J","year":"2022","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23156"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1089"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23383"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.522"},{"key":"e_1_2_9_18_1","first-page":"310","article-title":"Two\u2010year outcomes of radiofrequency device treatment of the nasal valve for nasal airway obstruction","volume":"62","author":"Silvers SL","year":"2024","journal-title":"Rhinology"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22861"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.2293"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.016"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70124-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556139307200118"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0232"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2018.05.004"},{"key":"e_1_2_9_27_1","unstructured":"American Academy of Otolaryngology\u2010Head and Neck Surgery (AAO\u2010HNS). Position Statement: Nasal Valve Repair. 2023. Accessed August 21 2024.https:\/\/www.entnet.org\/resource\/position-statement-nasal-valve-repair\/"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00087607"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098765"},{"key":"e_1_2_9_30_1","unstructured":"American Academy of Otolaryngology\u2013Head and Neck Surgery (AAO\u2010HNS). Position statement: nasal surgery and OSAS.2017. Accessed November 19 2024.https:\/\/www.entnet.org\/resource\/position-statement-nasal-surgery-and-osas\/"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.4.543"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24131"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202006-696FR"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2024.2340385"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.1118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:59:37Z","timestamp":1760950777000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.1118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,17]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ohn.1118"],"URL":"https:\/\/doi.org\/10.1002\/ohn.1118","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,17]]},"assertion":[{"value":"2024-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}