{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:19:33Z","timestamp":1785410373405,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aim to explore the differences in complication rates in endoscopic versus open transcervical treatment of Zenker diverticulum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective Cohort Study from January 1, 2015 to December 31, 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Queries of the TriNetX database's United States Collaborative Network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted using patients \u226518 years old diagnosed with Zenker diverticulum selected from the TriNetX United States Collaborative Network. Patients undergoing open and endoscopic diverticulectomy between 2015 and 2023 were identified and divided into cohorts and propensity score matched by age, sex, race, ethnicity, and common comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients that underwent transcervical approach (n\u2009=\u20091033), when compared to patients that underwent endoscopic approach (n\u2009=\u20092182), had higher rates of dysphonia (odds ratio [OR]: 2.44; 95% confidence interval [CI]: 1.47\u20104.05; <jats:italic>P<\/jats:italic>\u2009=\u2009.001), long\u2010term enteral feeding access (OR: 3.08; 1.74\u20105.46; <jats:italic>P<\/jats:italic>\u2009&gt;\u2009.001), and infection (OR: 6.65; 3.50\u201012.65; <jats:italic>P<\/jats:italic>\u2009&gt;\u2009.001). No significant difference was found in rates of esophageal perforation (OR: 1.60; 0.93\u20102.75; <jats:italic>P<\/jats:italic>\u2009=\u2009.087) or persistent postoperative dysphagia (OR: 1.03; 0.86\u20101.23, <jats:italic>P<\/jats:italic>\u2009=\u2009.75). There was no significant difference in the number of patients receiving repeat diverticulectomy procedures (OR: 0.83; 0.58\u20101.19; <jats:italic>P<\/jats:italic>\u2009=\u2009.314).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on analysis of a large healthcare database, endoscopic Zenker diverticulectomy is associated with rates of postoperative dysphonia, enteral feeding, and soft tissue infection. Both the open and endoscopic approaches offer relative advantages not captured by this population\u2010level analysis. Thus, judicious selection of patients based on comorbidities and anatomical factors is essential for optimizing outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1119","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T05:05:30Z","timestamp":1736226330000},"page":"1328-1333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Complications Following Surgical Management of Zenker Diverticulum: A Comparative Analysis of Endoscopic and Open Approaches"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9902-1437","authenticated-orcid":false,"given":"Jefferson","family":"DeKloe","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Thomas Jefferson University Hospital Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel R.","family":"Shing","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Thomas Jefferson University Hospital Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Herzig","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Bertoni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Thomas Jefferson University Hospital Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Tibbetts","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Thomas Jefferson University Hospital Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"StatPearls","author":"Nesheiwat Z","year":"2024"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"92","article-title":"Principles of surgical treatment of Zenker diverticulum","volume":"5","author":"Constantin A","year":"2012","journal-title":"J Med Life"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"219","article-title":"Zenker's diverticulum: exploring treatment options","volume":"33","author":"Bizzotto A","year":"2013","journal-title":"Acta Otorhinolaryngol 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