{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:20:18Z","timestamp":1787725218410,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effectiveness of platelet\u2010rich plasma (PRP) injection into the olfactory clefts of coronavirus disease 2019 (COVID\u201019) patients with persistent anosmia, hyposmia, and parosmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From March 2022 to July 2024, 514 COVID\u201019 patients undergoing PRP injection and olfactory training versus olfactory training (controls) for a persistent olfactory dysfunction (OD) were consecutively recruited from two medical centers. Subjects were evaluated from pre\u2010 to 3 months post\u2010injection with the olfactory disorder questionnaire (ODQ) and the threshold, discrimination, and identification (TDI) test. Olfactory outcomes were compared between controls and patients considering the type of OD (anosmia, hyposmia, and parosmia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PRP group was composed of 416 patients with anosmia (N\u2009=\u2009111; 26.7%), hyposmia (N\u2009=\u2009160; 38.5%), and parosmia (N\u2009=\u2009145; 34.9%). The baseline ODQ of patients with parosmia was significantly higher than those of the other groups (<jats:italic>P<\/jats:italic>\u2009=\u2009.001). The increase in TDI subscores and total score was significantly higher in all PRP subgroups compared to controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). The ODQ significantly reduced from pre\u2010 to post\u2010PRP injection in hyposmia and parosmia groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Patients with parosmia showed a significantly greater reduction in ODQ scores compared to the control group. The 3\u2010month TDI score was negatively influenced by the age of patients (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u2009\u22120.263; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and the duration of OD (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u2009\u22120.213; <jats:italic>P<\/jats:italic>\u2009=\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with parosmia experienced a stronger impact of OD on quality of life (QoL), and showed greater QoL improvement following PRP injections compared to other groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1149","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T09:15:06Z","timestamp":1738314906000},"page":"1450-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Platelet\u2010Rich Plasma for Treating COVID\u201019\u2010Related Anosmia, Hyposmia, and Parosmia: A Controlled Longitudinal Study"],"prefix":"10.1002","volume":"172","author":[{"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Polyclinic of Poitiers Elsan Poitiers France"},{"name":"Department of Surgery, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology University of Mons (UMons) Mons Belgium"},{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil Universit\u00e9 Versailles Saint\u2010Quentin\u2010en\u2010Yvelines (Paris Saclay University) Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"},{"name":"Department 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Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40136-016-0120-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08454-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08227-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12020141"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.357"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23116"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08885-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.460"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2022-000382"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12960"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0173-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5248-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24999"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-022-00598-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06810-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21655"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613221124773"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23363"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20230666"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-023-03553-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07560-y"},{"issue":"1","key":"e_1_2_9_23_1","first-page":"26","article-title":"Six 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