{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:43:15Z","timestamp":1761007395243,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Perioperative tobacco use is associated with poor wound healing postoperative complications. The purpose of this study is to use serum cotinine as a measure of tobacco consumption to evaluate complication rates and outcomes in patients undergoing septorhinoplasty procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care academic center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients &gt;18 years old undergoing septorhinoplasty from December 2017 to January 2023 were included. Serum cotinine levels were obtained on the day of surgery. Preoperative and postoperative nasal obstruction and septoplasty effectiveness (NOSE) scores were assessed. Postoperative wound complications were categorized as mild, moderate, and severe. Chi\u2010square, Fisher exact, and Kruskal\u2010Wallis tests were used to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven patients met inclusion criteria. Average age was 46 years, 31 patients were male, and 36 were female. Seven patients reported current tobacco use and 20 reported former use. Thirteen patients (19%) were cotinine\u2010positive, with a median level of 190\u2009ng\/mL. None of the cotinine\u2010positive patients had postoperative wound complications, whereas four of the cotinine\u2010negative patients did. There was no significant difference in the change in NOSE scores between the cotinine\u2010positive (\u221244.0) and cotinine\u2010negative (\u221245.3) groups (<jats:italic>P<\/jats:italic>\u2009=\u2009.70). Of the cotinine\u2010positive patients, the change in NOSE scores in patients who reported current tobacco use was \u221233.1 compared to \u221256.7 in patients who reported former tobacco use (<jats:italic>P<\/jats:italic>\u2009=\u2009.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum cotinine levels can be used for biochemical verification for tobacco use. Reported perioperative tobacco use may not be as predictive for effects on postoperative complications and functional outcomes in patients undergoing septorhinoplasty procedures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1212","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:57:28Z","timestamp":1742378248000},"page":"1904-1910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Outcomes in Septorhinoplasty Procedures Using Serum Cotinine as a Measure for Tobacco Use"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4053-4990","authenticated-orcid":false,"given":"Kimberly","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivam","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4110-8881","authenticated-orcid":false,"given":"Allison","family":"Keane","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonya S.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Division of Biostatistics and Bioinformatics, Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-5059","authenticated-orcid":false,"given":"Jessyka G.","family":"Lighthall","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"U.S. Department of Health and Human Services.The Health Consequences of Smoking\u201450 Years of Progress: A Report of the Surgeon General. U.S. Department of Health and Human Services Centers for Disease Control and Prevention National Center for Chronic Disease Prevention and Health Promotion Office on Smoking and Health;2014."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-0323"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.047"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2012.5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90623-J"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1572360"},{"key":"e_1_2_8_8_1","unstructured":"WattersC BrarS YapaSSeptoplasty.StatPearls.2024. Accessed June 17 2024.http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15283487"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000074980.39700.31"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/tc.2005.015263"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000297833.53794.27"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.7.1086"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntn010"},{"issue":"2","key":"e_1_2_8_14_1","first-page":"143","article-title":"Pharmacokinetics and metabolism of nicotine","volume":"57","author":"Tutka P","year":"2005","journal-title":"Pharmacological reports: PR"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1989.9935873"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.77.11.1435"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","unstructured":"Fourth national report on human exposure to environmental chemicals: updated tables. National Center for Environmental Health.2019. Accessed June 17 2024.doi:10.15620\/cdc75822","DOI":"10.15620\/cdc75822"},{"key":"e_1_2_8_18_1","unstructured":"Biomonitoring\u2014Cotinine. America's Children and the Environment;2019."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.1.3"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntz132"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.016"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7218a1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7244a1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.09.013"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.8.807"},{"issue":"3","key":"e_1_2_8_26_1","first-page":"219","article-title":"The effect of tobacco smoking on septoplasty outcomes: a prospective controlled study","volume":"19","author":"Yazici ZM","year":"2015","journal-title":"Hippokratia"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-021-02683-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjx023"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23345"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/22925503221085083"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2023.103811"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.1212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:07:04Z","timestamp":1760965624000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.1212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/ohn.1212"],"URL":"https:\/\/doi.org\/10.1002\/ohn.1212","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"2024-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}