{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:42:22Z","timestamp":1791830542420,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The minimal clinically important difference (MCID) represents the smallest change in treatment outcome deemed clinically meaningful. This study estimates the MCID for 2 widely used tinnitus measures: the Tinnitus Handicap Inventory (THI) and the Tinnitus Functional Index (TFI), using anchor\u2010based approaches while accounting for baseline severity and time interval.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A multi\u2010center randomized clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>European tinnitus centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Anchor\u2010based approaches, including the effect size, receiver\u2010operating characteristics, and \u0394THI\/TFI methods, were employed to determine the MCID. The \u201cminimally improved\u201d category of the Clinical Global Impression Scale\u2010Improvement (CGI\u2010I) served as the anchor. The standard error of measurement was used to assess random variation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For the THI, MCID estimates ranged from 7.8 to 12, with a point estimate of 11 after 12 weeks of treatment (N\u2009=\u2009364). For the TFI, MCID estimates ranged from 7.3 to 9.4, with a point estimate of 9 points after 12 weeks (N\u2009=\u2009359). Both measures indicated that higher baseline severity and longer time intervals required greater score reduction for clinical relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the context\u2010specific nature of MCID values for tinnitus measures and emphasizes the need for consensus on optimal anchor\u2010based approaches to improve comparability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.1217","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T01:20:26Z","timestamp":1742692826000},"page":"69-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Estimation of Minimal Clinically Important Difference for Tinnitus Handicap Inventory and Tinnitus Functional 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Schlee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Regensburg Regensburg Germany"},{"name":"Institute for Information and Process Management Eastern Switzerland University of Applied Sciences St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schoisswohl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Regensburg Regensburg Germany"},{"name":"Department of Human Sciences Institute of Psychology Universitaet der Bundeswehr M\u00fcnchen Neubiberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rilana","family":"Cima","sequence":"additional","affiliation":[{"name":"Department of Health Psychology Katholieke Universiteit Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Kikidis","sequence":"additional","affiliation":[{"name":"First Department of Otorhinolaryngology\u2013Head and Neck Surgery Hippocrateion General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Lopez\u2010Escamez","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery Instituto de Investigacion Biosanitaria, ibs.GRANADA Universidad de Granada Granada Spain"},{"name":"Meniere's Disease Neuroscience Research Program, Faculty of Medicine and Health School of Medical Sciences, The Kolling Institute University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Tinnitus Center, Charit\u00e9 \u2013 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