{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:43:14Z","timestamp":1771026194251,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Patients with human papillomavirus (HPV)\u2010related oropharyngeal squamous cell carcinoma (OPSCC), particularly of the base of tongue, have a high rate of occult nodal disease in the contralateral neck. The risk of failure in the contralateral neck is reduced with elective treatment. The optimal treatment strategy to minimize treatment\u2010related toxicity while preserving regional control in the contralateral neck has not been elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional study of patients who underwent elective contralateral neck dissection as part of primary surgical treatment for HPV\u2010related OPSCC between January 2002 and December 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent elective contralateral neck dissection as part of primary surgical treatment for HPV\u2010related OPSCC between January 2002 and December 2018 were selected for inclusion. Long\u2010term patient\u2010reported functional outcomes were assessed via telephone at the time of data collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 64 patients met the criteria for inclusion with a median follow\u2010up of 58.5 months. In total, 56 patients (88%) had a primary cancer within the base of tongue or glossotonsillar sulcus. In total, 12 patients (19%) were found to have occult nodal metastasis in the contralateral neck, of whom 9 received adjuvant contralateral neck radiation. None of the patients who had node\u2010negative contralateral neck dissections went on to receive radiation in the contralateral neck. Two patients (3%) recurred locally, two patients (3%) developed ipsilateral regional recurrence, and four patients (6%) developed distant metastasis. There were no regional recurrences within the contralateral neck. Five\u2010year progression\u2010free survival was 82.0%, whereas 5\u2010year locoregional control was 93.0%. The mean Neck\u2010Dissection Impairment Index was 94.4 with a median interval time of 92 months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elective contralateral neck dissection in patients with HPV\u2010related OPSCC provides excellent regional control with minimal long\u2010term functional impairment, and most patients can be spared contralateral neck radiation without compromising oncologic outcomes. This may decrease long\u2010term toxicity related to bilateral neck irradiation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1227","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:58:26Z","timestamp":1742378306000},"page":"1954-1961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Outcomes After Elective Contralateral Neck Dissection for HPV\u2010Related Oropharyngeal Cancer"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7501-9089","authenticated-orcid":false,"given":"Ray Y.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-5537","authenticated-orcid":false,"given":"Molly E. 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