{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:43:54Z","timestamp":1790181834732,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Vestibular schwannomas influence the magnetic resonance (MR) signal intensity (SI) in the vestibular cistern and cochlear perilymph. The aim of this study is to evaluate the relationship between perilymphatic signal changes on gradient\u2010echo T2\u2010weighted 3\u2009T MR sequence and the clinical symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The study was conducted at the Institute of Image\u2010Guided Surgery in Strasbourg, France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with vestibular schwannoma who underwent magnetic resonance imaging at our institution between 2008 and 2016 were retrospectively reviewed. A control group consisted of individuals without past or present otological symptoms. The vestibular schwannomas were divided into three groups, based on the degree of internal auditory canal obstruction. The SI ratios of the vestibular cistern to cerebrospinal fluid (CSF) and cochlea to CSF were compared with clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 172 patients with vestibular schwannoma and 61 controls. Vestibular schwannoma was associated with a significant decrease of the SI ratio of the vestibular cistern to CSF (0.716\u2009\u00b1\u20090.297 vs 1.06\u2009\u00b1\u20090.21, <jats:italic>P<\/jats:italic>\u2009=\u2009.004) and cochlea to CSF (0.66\u2009\u00b1\u20090.199 vs 0.903\u2009\u00b1\u20090.011, <jats:italic>P<\/jats:italic>\u2009=\u2009.004) compared to controls, with significant negative correlation between both the SI ratios of the vestibular cistern and cochlea to CSF with tumor volume (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Among all the symptoms studied, the SI ratio of the cistern normalized by CSF was significantly associated with progressive hearing loss (<jats:italic>P<\/jats:italic>\u2009=\u2009.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Perilymphatic vestibular cistern and cochlear SI changes appear to be a promising noninvasive biomarker for hearing impairment in vestibular schwannoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1228","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T10:07:09Z","timestamp":1742378829000},"page":"185-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Perilymphatic Signal Changes in Vestibular Schwannoma: A Potential Biomarker of Progressive Hearing Loss?"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-4662","authenticated-orcid":false,"given":"Anne Ren\u00e9e Juliette","family":"P\u00e9port\u00e9","sequence":"first","affiliation":[{"name":"Department of Radiology Cantonal Hospital Frauenfeld Frauenfeld Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Gallix","sequence":"additional","affiliation":[{"name":"Department of Radiology, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Strasbourg Strasbourg France"},{"name":"American Hospital of Paris Neuilly\u2010sur\u2010Seine France"},{"name":"INRIA, Institut national de recherche en sciences et technologies du num\u00e9rique Paris France"},{"name":"Department of Diagnostic Radiology, Montreal General Hospital Site Mc Gill University Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00efna","family":"Venkatasamy","sequence":"additional","affiliation":[{"name":"Department of Radiology Institute of Image\u2010Guided Surgery Strasbourg France"},{"name":"ICube UMR 7357, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg Universit\u00e9 de Strasbourg\/CNRS Illkirch France"},{"name":"Plateforme Imageries du Vivant Universit\u00e9 de Paris, PARCC, INSERM Paris France"},{"name":"Department of Radiology \u2013 Medical Physics University Hospital Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz153"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209130872"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr200346q"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00978"},{"issue":"6","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198442","article-title":"The proteome of perilymph in patients with vestibular schwannoma. 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