{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:43:45Z","timestamp":1783183425708,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of modified central\u2010part laryngectomy with pharyngeal space reduction (CPL\u2010PR) on patients with weak deglutitive pharyngeal contraction, as seen in late\u2010stage amyotrophic lateral sclerosis (ALS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single\u2010institution academic center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with late\u2010stage ALS confined at The University of Tokyo Hospital between 2019 and March 2024 in whom CPL\u2010PR had been performed were identified. Patients who had undergone simultaneous pharyngeal flap surgery or had no preoperative high\u2010resolution manofluorography done were excluded. Preoperatively, penetration\u2010aspiration scale (PAS) scores were determined via videofluoroscopic swallowing study. Functional oral intake scale (FOIS) scores and high\u2010resolution manometric parameters were measured and compared preoperatively and postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients were identified with a median age of 66.5 (interquartile range [IQR]: 58.0\u201074.8). The median preoperative PAS score was 7.5 (IQR: 5.5\u20108.0), indicating severe dysphagia. There was significant improvement in oral intake status with FOIS scores increasing from 1 (IQR: 1\u20101) to 3 (IQR: 2\u20103) at 3 months postoperatively (<jats:italic>P<\/jats:italic>\u2009=\u2009.0002). Significant increases in velopharyngeal closure integral (<jats:italic>P<\/jats:italic>\u2009=\u2009.024) and mesohypopharyngeal contractile integral (<jats:italic>P<\/jats:italic>\u2009=\u2009.0001) were observed. Upper esophageal sphincter (UES) resting pressure was reduced (<jats:italic>P<\/jats:italic>\u2009=\u2009.0002), and UES relaxation time was prolonged during swallowing (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were tangible improvements in pharyngeal contraction, UES bolus passage, and oral intake status following CPL\u2010PR, which contribute to regaining oral intake in late\u2010stage ALS. CPL\u2010PR is an option for patients requiring tracheostomy who wish to prevent aspiration and regain their ability to take food orally.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1229","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:36:26Z","timestamp":1742376986000},"page":"154-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improved Pharyngeal Contraction and Oral Intake Status After Modified Central\u2010Part Laryngectomy for Late\u2010Stage ALS"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-7237","authenticated-orcid":false,"given":"Rumi","family":"Ueha","sequence":"first","affiliation":[{"name":"Swallowing Center The University of Tokyo Hospital Tokyo Japan"},{"name":"Department of Otolaryngology, and Head and Neck Surgery, Faculty of Medicine The University of Tokyo Tokyo 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