{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:14:52Z","timestamp":1791303292689,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Reliable variables for detecting pediatric obstructive sleep apnea (OSA) using three\u2010dimensional (3D) imaging are currently lacking. This study aimed to develop a novel predictor of OSA in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care children's hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pediatric patients (&lt;18 years) with symptoms suggestive of OSA were enrolled. Polysomnography was used to categorize disease severities as primary snoring (apnea\u2010hypopnea index, AHI\u2009&lt;\u20091), mild OSA (AHI\u2009=\u20091\u20105), moderate OSA (AHI\u2009=\u20095\u201010), and severe OSA (AHI\u2009&gt;\u200910). Cone\u2010beam computed tomography was used to obtain 3D images. The minimal to mean airway area (AA) ratio was measured across the entire pharynx and its segment (nasopharynx, oropharynx, and hypopharynx).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 104 children. For the entire pharynx, the minimal to mean AA ratio was 0.41, 0.36, 0.35, and 0.25 in the primary snoring, mild OSA, moderate OSA, and severe OSA groups, respectively (<jats:italic>P<\/jats:italic>\u2009=\u2009.001). Pearson's correlation revealed an inverse relationship between the minimal to mean AA ratio and OSA severity. The receiver operating characteristic curve identified the optimal cutoff point for predicting AHI\u2009\u2265\u20091 as 0.34 in the oropharynx (area under the curve [AUC]\u2009=\u200971%) and 0.39 in the entire pharynx (AUC\u2009=\u200967%). The minimal to mean AA ratio in the nasopharynx or hypopharynx indicated no significant difference between OSA severities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A minimal to mean airway AA ratio of less than one\u2010third in the pharynx serves as a novel predictor of pediatric OSA in 3D imaging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1234","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:47:16Z","timestamp":1742377636000},"page":"2124-2133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Minimal to Mean Airway Area Ratio of the Pharynx: A Novel Predictor of Pediatric Obstructive Sleep Apnea in Three\u2010Dimensional 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