{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:07:04Z","timestamp":1789132024610,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the diagnostic accuracy of various combinations of patient\u2010reported outcome measures (PROMs) and upper aerodigestive tract finding instruments dedicated to the clinical diagnosis of laryngopharyngeal reflux disease (LPRD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective, multicenter study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with LPRD at the 24\u2010hour hypopharyngeal\u2010esophageal multichannel intraluminal impedance\u2010pH monitoring were recruited from three European hospitals. Asymptomatic individuals served as the control group. Participants completed the Reflux Symptom Index (RSI), Reflux Symptom Score (RSS), and Reflux Symptom Score\u201012 (RSS\u201012) at baseline and 3\u2010month posttreatment. Clinical signs were evaluated with the Reflux Finding Score (RFS), Reflux Sign Assessment (RSA), and Reflux Sign Assessment\u201010 (RSA\u201010). Sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV) were calculated for each instrument and their combinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 542 LPRD patients and 204 healthy controls were included. The RSS was the PROM with the highest SE (95.4%), whereas RSS\u201012 reported the highest SP (94.7%). RSA had the highest SE (94.0%), and RSA\u201010 reported the highest SP (76.3%). The highest SE and SP of combination tools were found for RSS+RSA (90.4%) and RSS+RSA\u201010 (99.4%), respectively. RSS+RSA\u201010 achieved the highest PPV value (99.7%) and RSS+RSA had the highest NPV (79.3%). Overall, the RSS demonstrated the greatest diagnostic accuracy with an area under the curve (AUC) of 0.985. The combination RSS+RSA reported an AUC of 0.934.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of RSS and RSA provided the most accurate diagnostic performance, maximizing SE, SP, PPV, and NPV. This combination offers enhanced utility for the preliminary diagnosis of LPRD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.1237","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T02:23:11Z","timestamp":1742869391000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic Accuracy of Patient\u2010Reported Outcome Measures and Finding Instruments in Laryngopharyngeal Reflux Disease"],"prefix":"10.1002","volume":"173","author":[{"given":"Catherine","family":"Muscato","sequence":"first","affiliation":[{"name":"Department of Surgery UMONS Research Institute for Health Sciences and Technology, Faculty of Medicine University of Mons (UMons) Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome R.","family":"Lechien","sequence":"additional","affiliation":[{"name":"Department of Surgery UMONS Research Institute for Health Sciences and Technology, Faculty of Medicine University of Mons (UMons) Mons Belgium"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Foch Hospital, School of Medicine University Paris Saclay Paris France"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"},{"name":"Department of Otolaryngology Elsan Hospital Paris 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