{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:49:57Z","timestamp":1792518597014,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to assess the feasibility and safety of a cochlear catheter (cannula) for inner ear drug delivery during cochlear implantation. We evaluated the otoprotective effect of L\u2010N\u2010acetylcysteine (L\u2010NAC) administered via a cannula in combination with a dexamethasone\u2010eluting cochlear implant (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>An animal model study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Animal facility of an academic institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Animals were divided into 8 groups: (1) implantation with a CI; (2) implantation with a dexamethasone\u2010eluting CI (CIDexel); (3) cannula injection of artificial perilymph (Can+AP); (4) cannula injection of Ringer (Can+R); (5) cannula injection of R and CI (Can+CI); (6) cannula injection of R and Dexel (Can+Dexel); (7) cannula injection of 2\u2009mM L\u2010NAC and CI (Can L\u2010NAC 2\u2009mM+CI); or (8) cannula injection of 2mM L\u2010NAC and Dexel (Can L\u2010NAC 2\u2009mM++Dexel). The contralateral ear served as the control group. Hearing thresholds were determined preoperatively, and at postoperative day (POD 7) and POD 30 post\u2010cochlear implantation, using auditory brainstem responses (ABRs). The organ of Corti dissections were performed at POD 30 for hair cell (HC) viability, and oxidative stress assessment using immunostaining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The L\u2010NAC (2\u2009mM) and dexamethasone\u2010eluting electrode group had significantly lower hearing thresholds than the standard CI, Can L\u2010NAC 2\u2009mM, and Dexel groups. The animal group treated with L\u2010NAC (2\u2009mM) and dexamethasone\u2010eluting electrode showed higher HC viability and reduced oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An intracochlear cannula can deliver pharmaceutical interventions without causing additional hearing loss. L\u2010NAC presents strong anti\u2010apoptotic potential and administration through a cannula together with Dexel implantation, and achieves a synergistic effect enhancing the otoprotection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.1252","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:39:03Z","timestamp":1745566743000},"page":"208-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intracochlear Drug Delivery Using a Catheter and Dexamethasone\u2010Eluting Electrode Preserves Residual Hearing Post\u2010Cochlear Implantation"],"prefix":"10.1002","volume":"173","author":[{"given":"Maria\u2010Pia","family":"Tuset","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimee N.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Ebode","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeenu","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Garnham","sequence":"additional","affiliation":[{"name":"MED\u2010El GmBh Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Melchionna","sequence":"additional","affiliation":[{"name":"MED\u2010El GmBh Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Hessler","sequence":"additional","affiliation":[{"name":"MED\u2010El GmBh Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"Schilp","sequence":"additional","affiliation":[{"name":"MED\u2010El GmBh Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Godur","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keelin","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien A.","family":"Eshraghi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine Miami Florida USA"},{"name":"Department of Neurological Surgery University of Miami Miller School of Medicine Miami Florida USA"},{"name":"Department of Biomedical Engineering University of Miami Coral Gables Florida USA"},{"name":"Department of Pediatrics University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.21.285643"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/audiolres12040042"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12050649"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12040529"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2018.11.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1256499"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000244355.34577.85"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joto.2021.03.001"},{"issue":"1","key":"e_1_2_8_10_1","first-page":"1","article-title":"Molecular mechanisms involved in cochlear implantation trauma and the protection of hearing and auditory sensory cells by inhibition of c\u2010Jun\u2010N\u2010terminal kinase signaling","volume":"123","author":"Eshraghi AA","year":"2013","journal-title":"Laryngoscope"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.08.018"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941312200107"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000173169.45262.ae"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00113"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008701"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2018.1440086"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030716"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1134809"},{"issue":"3","key":"e_1_2_8_19_1","first-page":"236","article-title":"Are intratympanic injections of N\u2010acetylcysteine and methylprednisolone protective against Cisplatin\u2010induced ototoxicity?","volume":"39","author":"Saliba I","year":"2010","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2009.08.010"},{"issue":"1","key":"e_1_2_8_21_1","first-page":"87","article-title":"Cisplatin otoprotection using transtympanic L\u2010N\u2010acetylcysteine: a pilot randomized study in head and neck cancer patients","volume":"124","author":"Yoo J","year":"2014","journal-title":"Laryngoscope"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31822e006d"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195230"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181ab8fba"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1030771"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12010002"},{"issue":"1","key":"e_1_2_8_27_1","article-title":"Local inner ear application of dexamethasone in cochlear implant models is safe for auditory neurons and increases the neuroprotective effect of chronic electrical stimulation","volume":"12","author":"Scheper V","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1179\/1754762811Y.0000000024"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00492"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.02.003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.107825"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183374"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-018-0539-z"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00258"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1179\/146701010X12671177204309"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1179\/146701010X12671177204345"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31805778fc"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2021.108228"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31815aee21"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2021.108224"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002383"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31818173ec"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1202429"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1179\/1754762813Y.0000000053"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200309000-00003"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000004134"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.1252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:24:25Z","timestamp":1760963065000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.1252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/ohn.1252"],"URL":"https:\/\/doi.org\/10.1002\/ohn.1252","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"2024-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}