{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T21:55:55Z","timestamp":1776808555090,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Evaluate the effect of deintensified postoperative adjuvant (chemo)radiation therapy (POA(C)RT) on patient\u2010reported dysphagia outcomes in patients with human papillomavirus (HPV+)\u2009oropharyngeal squamous cell carcinoma (OPSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multiple institutions, 2014 to 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with HPV+\u2009OPSCC underwent transoral robotic surgery and reduced\u2010dose POA(C)RT by pathologic risk stratification. The Minimalist Trial (MINT) participants received 42\u2009Gy radiation therapy (RT) with one dose of cisplatin 100\u2009mg\/m<jats:sup>2<\/jats:sup> (intermediate\u2010risk arm) or no cisplatin (low\u2010risk arm). The intermediate\u2010risk E3311 participants were randomized to 50 or 60\u2009Gy RT. Analysis was per\u2010protocol by RT dose group. The primary outcome was change in MD Anderson Dysphagia Inventory (MDADI) composite score from baseline to 1\u2010year posttreatment, with a clinically meaningful decline (CMD) of \u226510 points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 156 included patients received POA(C)RT: n\u2009=\u200928 at 42 to 49\u2009Gy (n\u2009=\u200919 no cisplatin, n\u2009=\u20099 cisplatin), n\u2009=\u200982 at 50 to 59, and n\u2009=\u200946 at 60\u2009Gy. Mean (SD) change in MDADI was \u22127.2 (10.6) in the 42 to 49\u2009Gy group, \u221211.3 (17.2) in the 50 to 59 group, and \u22129.1 (15.1) in the 60\u2009Gy group (analysis of variance [ANOVA] <jats:italic>P<\/jats:italic>\u2009=\u2009.46). The rate of CMD was 11\/28 (39%) in the 42 to 49\u2009Gy group, 43\/82 (52%) in the 50 to 59 group, and 20\/46 (44%) in the 60\u2009Gy group (chi\u2010square <jats:italic>P<\/jats:italic>\u2009=\u2009.42). The rate of CMD was similar in those receiving 42 to 49\u2009Gy with (3\/9, 33%) and without cisplatin (8\/19, 42%) (diff. 1%, 95% CI \u221229% to 47%). Gastrostomy tube rates were similar across dose groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changes in dysphagia\u2010related quality\u2010of\u2010life (MDADI) from baseline to 1 year after POA(C)RT did not differ by radiation dose in the range of 42 to 60 Gy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1261","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T03:45:31Z","timestamp":1748403931000},"page":"410-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patient\u2010Reported Swallowing Outcomes in HPV+ Oropharyngeal Cancer by Postoperative Chemoradiation Dose in MINT and E3311"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-2343","authenticated-orcid":false,"given":"Theresa","family":"Tharakan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery 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Medicine St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Adkins","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Washington University School of Medicine St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Oppelt","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Washington University School of Medicine St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wade","family":"Thorstad","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Washington University School of Medicine St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiram","family":"Gay","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Washington University School of Medicine St Louis Missouri 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