{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:37:49Z","timestamp":1792427869931,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the association between body mass index (BMI) and histopathological features and postoperative recurrence risk of chronic rhinosinusitis with nasal polyps (CRSwNP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A retrospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Recurrent group and nonrecurrent group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited CRSwNP patients who underwent functional endoscopic sinus surgery and classified them into three groups based on BMI: normal weight, overweight, and obesity. All patients were followed for 3 years and divided into recurrence and nonrecurrence groups. The histopathological features and the impact of BMI on the risk of postoperative recurrence were analyzed through comparative analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 577 CRSwNP patients completed the follow\u2010up, with 197 experiencing postoperative recurrence. Recurrence rates, tissue eosinophil counts, and interleukin (IL)\u20105 and IL\u201017A expression levels were significantly higher in the overweight and obesity groups compared to the normal weight group. Additionally, within the overweight and obesity groups, patients with recurrence had elevated tissue eosinophil counts and IL\u20105 and IL\u201017A levels compared to the other two groups. Notably, tissues collected during revision surgery showed increased eosinophil counts, IL\u20105 and IL\u201017A levels compared to baseline, particularly in obese patients. Both logistic regression analyses and Kaplan\u2010Meier curves indicated that overweight and obesity were associated with an increased risk of CRSwNP recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated BMI presented significant impacts on the histopathological changes and the risk of postoperative recurrence in CRSwNP patients. Overweight and obesity aggravated tissue eosinophil infiltration, and IL\u20105 and IL\u201017A expressions contributing to the recurrent mechanisms of CRSwNP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1285","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T09:56:02Z","timestamp":1746438962000},"page":"522-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Elevated Body Mass Index Aggravates Histopathological Changes and Postoperative Recurrence Risk in Nasal Polyps"],"prefix":"10.1002","volume":"173","author":[{"given":"Sijie","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha Hunan People's Republic of China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha Hunan People's Republic of 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