{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:18:41Z","timestamp":1791980321489,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our study objectives were to evaluate the relationship between Thyroid Imaging Reporting and Data System (TI\u2010RADS) and Bethesda classification and to compare both TI\u2010RADS and Bethesda classification for the diagnosis of papillary thyroid carcinoma (PTC) within the pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic pediatric hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 13\u2010year retrospective review was performed of all pediatric patients undergoing thyroid fine needle aspiration (FNA) and ultrasound at our institution. Demographics, TI\u2010RADS scoring, FNA results, surgical history, and final pathology were collected. High\u2010risk ultrasonography and cytopathology were defined as TI\u2010RADS 3\u20105 and Bethesda 5\u20106, respectively. Spearman's rank correlation was determined for TI\u2010RADS and Bethesda classification. Relative risks of high\u2010risk TI\u2010RADS and Bethesda classification for predicting PTC were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 157 patients (21.7% male, median age at time of FNA 15 years, and range 2.7\u201021 years) underwent ultrasound and FNA during the study. The Spearman's rank correlation coefficient for TI\u2010RADS compared with the Bethesda classification was 0.41 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The relative risk of high\u2010risk TI\u2010RADS scores to predict the presence of PTC was 7.99 (95% CI 1.16\u201054.90). High\u2010risk Bethesda classification demonstrated a relative risk for predicting PTC of 6.62 (95% CI 4.22\u201010.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our cohort, there was a moderate correlation between TI\u2010RADS and Bethesda classifications. Patients with a TI\u2010RADS score\u2009\u22653 and Bethesda classification 3 or 4 are at intermediate risk for harboring PTC and should be counseled accordingly.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1310","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:35:49Z","timestamp":1747370149000},"page":"985-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["TI\u2010RADS and Bethesda Classification System Correlate With Predicting Pediatric Papillary Thyroid Carcinoma"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7947-4724","authenticated-orcid":false,"given":"Shaunak N.","family":"Amin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Branson","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Nathaniel","family":"Perkins","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery Seattle Children's Hospital Seattle Washington USA"},{"name":"Walter Reed National Military Medical Center Division of Pediatric Otolaryngology\u2013Head and Neck Surgery Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Seattle Children's Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler G.","family":"Ketterl","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Seattle Children's Hospital Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedieh","family":"Khalatbari","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology St. Jude's Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay R.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington Seattle Washington USA"},{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery Seattle Children's Hospital Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington Seattle Washington USA"},{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery Seattle Children's Hospital Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington Seattle Washington USA"},{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery Seattle Children's Hospital Seattle Washington USA"},{"name":"Division of Pediatric Otolaryngology\u2013Head and Neck Surgery Children's Mercy Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-017-3974-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.02.034"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2015.07.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2017.01.046"},{"issue":"9","key":"e_1_2_8_6_1","first-page":"1039","article-title":"The 2023 Bethesda system for reporting thyroid cytopathology","volume":"33","author":"Ali SZ","year":"2023","journal-title":"Thyroid"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0460"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2022.111411"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22254"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"147","article-title":"Accuracy of Bethesda system in the diagnosis of thyroid nodules: utility of combined histopathological and radiological reporting systems","volume":"5","author":"Fawzy M","year":"2021","journal-title":"Egypt J of Cancer and Biomed Res"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8095378"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30347"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.16257"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.1310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:30:27Z","timestamp":1758796227000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.1310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ohn.1310"],"URL":"https:\/\/doi.org\/10.1002\/ohn.1310","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"assertion":[{"value":"2024-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}