{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:03:11Z","timestamp":1790247791838,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to describe the audiological outcomes of cytomegalovirus (CMV)\u2010positive newborns detected through universal screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Three nurseries and a neonatal intensive care unit in Memphis, Tennessee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were analyzed from patients screened for congenital CMV (cCMV) by saliva polymerase chain reaction from March 2016 to May 2024. Newborns were classified based on symptoms at birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 247 CMV\u2010positive newborns (134 males, 54.2%), 77 (31.17%) were symptomatic. Among these, 16 were diagnosed with sensorineural hearing loss (SNHL): 12 bilateral SNHL (BHL), 4 with unilateral SNHL (UNHL). Three symptomatic patients developed late\u2010onset UNHL. Four of the asymptomatic newborns developed UNHL, and one BHL, within the first year of life. Fifty\u2010eight patients received valganciclovir. Among the patients who eventually developed SNHL, 5\/10 treated experienced worsening or lack of improvement; 10\/14 untreated cases showed hearing deterioration or did not improve, and 2\/14 remained stable. Patients with SNHL had higher rates of microcephaly and intracranial calcifications compared to those with normal hearing but showed no differences in urine CMV viral load at birth. In the current cohort, nine patients have cochlear implants (seven bilateral, one unilateral) and four have hearing aids (three bilateral, one unilateral). Social vulnerability was associated with fewer follow\u2010ups in patients with SNHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study underscores the profound impact of cCMV infection on hearing outcomes, even when asymptomatic at birth. It reinforces the importance of universal cCMV screening programs to identify infants at risk for SNHL. It also highlights the impact of social determinants of health on long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.1332","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T09:50:31Z","timestamp":1749721831000},"page":"1245-1253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Audiological Outcomes of Cytomegalovirus Saliva PCR\u2010Positive Newborns in Support of Universal Screening"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-7879","authenticated-orcid":false,"given":"Celine","family":"Richard","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Division of Pediatric Otolaryngology Le Bonheur Children's Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8118-4088","authenticated-orcid":false,"given":"Leyn","family":"Shakhtour","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; 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