{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:43:59Z","timestamp":1790649839781,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinical presentation and weaning of patients with chronic proton pump inhibitor (PPI) therapy and laryngopharyngeal reflux disease (LPRD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with LPRD symptoms despite ongoing PPI therapy were prospectively recruited from two centers. LPRD diagnosis required &gt;1 pharyngeal reflux event on hypopharyngeal\u2010esophageal multichannel intraluminal impedance\u2010pH monitoring (HEMII\u2010pH) or reflux symptom score (RSS)\u2009&gt;\u200913 with reflux sign assessment (RSA)\u2009&gt;\u200914. A control group with primary LPRD diagnosis was established. All patients received diet modifications, lifestyle changes, and alginate\/antacid therapy for 3 months while discontinuing PPIs. Clinical presentations and treatment responses were compared between groups using RSS and RSA. PPI weaning success rates and rebound effects were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three patients with PPI therapy and 53 subjects with a primary LPRD diagnosis were consecutively recruited. PPIs were successfully discontinued in 66.0% of patients, with rebound effects occurring in 20.0% of weaned cases. Long\u2010term PPI users (mean duration: 142.3\u2009\u00b1\u2009153.9 months) exhibited significantly higher otolaryngological and respiratory symptoms than primary LPRD patients, while both groups showed comparable digestive symptoms. Only 5.7% of patients met criteria for long\u2010term PPI therapy. Both groups demonstrated significant improvement in symptoms and signs following treatment. The PPI group showed greater reduction in reflux sign assessment scores (<jats:italic>P<\/jats:italic>\u2009=\u2009.001) compared to primary LPRD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The chronic PPI consumption was not supported by clinical guidelines in most patients with LPRD. Most long\u2010term PPI users with LPRD can successfully discontinue therapy when replaced with appropriate anti\u2010reflux treatment alternatives.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.1368","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T10:49:31Z","timestamp":1753786171000},"page":"888-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Profiles and Proton Pump Inhibitor Discontinuation Outcomes in Laryngopharyngeal Reflux Disease"],"prefix":"10.1002","volume":"173","author":[{"given":"Lea","family":"Geoffroy","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Mons (UMons) Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome R.","family":"Lechien","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Mons (UMons) Mons Belgium"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Foch Hospital, School of Medicine University Paris Saclay Paris France"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"},{"name":"Department of Otolaryngology Elsan Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31134"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.12.1534"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4142-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S6862"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000408"},{"key":"e_1_2_9_7_1","unstructured":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament. PPIs use: an observational study from 2015 health insurance data [Internet]. 2018 Dec [cited 2022 Jul 22].https:\/\/www.epi-phare.fr\/app\/uploads\/2020\/04\/EPI-PHARE_2018_utilisation_IPP.pdf"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-09181-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419888947"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330616"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489416686586"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.69"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08881-w"},{"key":"e_1_2_9_16_1","unstructured":"INAMI data; 2023. Consulted March 27 2025.https:\/\/www.inami.fgov.be\/fr\/themes\/soins-de-sante-cout-et-remboursement\/les-prestations-de-sante-que-vous-rembourse-votre-mutualite\/medicaments\/remboursement-d-un-medicament\/specialites-pharmaceutiques-remboursables\/liste-des-specialites-pharmaceutiques-les-chapitres\/indicateurs-inhibiteurs-de-la-pompe-a-protons"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-022-01941-2"},{"key":"e_1_2_9_18_1","unstructured":"ChevreulK.S\u00e9curit\u00e9 Sociale. Les prescriptions d'IPP \u2010 Rapport de la Commission des comptes de la S\u00e9curit\u00e9 Sociale [Internet];2009."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39416.559942.BE"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.674"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1283"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30322"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13518"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816648298"},{"key":"e_1_2_9_25_1","article-title":"Pharmacological and biological relevance in the medical treatment of laryngopharyngeal reflux: a state\u2010of\u2010the\u2010art review","author":"Lechien JR","year":"2024","journal-title":"J Voice"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105459"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.1368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:29:52Z","timestamp":1758796192000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.1368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ohn.1368"],"URL":"https:\/\/doi.org\/10.1002\/ohn.1368","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,29]]},"assertion":[{"value":"2025-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}