{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:05Z","timestamp":1761007445412,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to prospectively evaluate the olfactory function in a series of individuals infected with SARS\u2010CoV\u20102 and who had undergone psychophysical olfactory assessment prior to infection.\u00a0Individuals unexposed to SARS\u2010CoV\u20102 infection underwent a psychophysical evaluation of smell with the Sniffin' Sticks test. The subjects were followed prospectively and included in the study if they developed SARS\u2010CoV\u20102 infection with a second test 60 days after recovery. At the 60\u2010day follow\u2010up of the 41 included subjects, 2 (4.9%) self\u2010reported persistent olfactory dysfunction (OD). The differences between TDI scores before and after infection were statistically significant (37 [interquartile range (IQR), 34.25\u201039.25] vs\u00a034.75 [IQR, 32.25\u201038]; <jats:italic>p<\/jats:italic>\u2009=\u2009.021). Analyzing the individual olfactory domains, the differences were significant for threshold (T) (9.75 [IQR, 9\u201011.25] vs\u00a08.25 [IQR, 7.25\u201010.25]; <jats:italic>p<\/jats:italic>\u2009=\u2009.009) but not for odor discrimination (D) (<jats:italic>p<\/jats:italic>\u2009=\u2009.443) and identification (I) (<jats:italic>p<\/jats:italic>\u2009=\u2009.159). SARS\u2010CoV\u20102 causes a significant reduction in the olfactory function, in particular affecting the olfactory threshold, even in subjects who do not self\u2010report an OD.<\/jats:p>","DOI":"10.1002\/ohn.166","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T15:58:00Z","timestamp":1677167880000},"page":"1249-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SARS\u2010CoV\u20102 Effects on Psychophysical Olfactory Scores: Prospective Study With Evaluation Before and 60\u2010Days After Infection"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-145X","authenticated-orcid":false,"given":"Luigi Angelo","family":"Vaira","sequence":"first","affiliation":[{"name":"Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences University of Sassari Sassari Italy"},{"name":"Biomedical Science Department, PhD School of Biomedical Science University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome R.","family":"Lechien","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Experimental Oncology, Mons School of Medicine, Research Institute for Health Sciences and Technology University of Mons (UMons) Mons Belgium"},{"name":"Department of Otolaryngology\u2013Head Neck Surgery Elsan Polyclinic of Poitiers Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Salzano","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences University of Sassari Sassari Italy"},{"name":"Department of Maxillofacial Surgery University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Maglitto","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences University of Sassari Sassari Italy"},{"name":"Department of Maxillofacial Surgery University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Boscolo\u2010Rizzo","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology, Department of Medical, Surgical and Health Sciences University of Trieste Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Hopkins","sequence":"additional","affiliation":[{"name":"ENT department King's College London UK"},{"name":"British Rhinological Society (President) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"De Riu","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29286"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22923"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9080627"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211061511"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.3993"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0173-0"},{"key":"e_1_2_8_8_1","first-page":"517","article-title":"High prevalence of long\u2010term olfactory, gustatory, and chemesthesis dysfunction in post\u2010COVID\u201019 patients: a matched case\u2010control study with one\u2010year follow\u2010up using a comprehensive psychophysical evaluation","volume":"59","author":"Boscolo\u2010Rizzo P","year":"2021","journal-title":"Rhinology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2021.1899282"},{"key":"e_1_2_8_10_1","unstructured":"Monitoring of the SARS\u2010CoV\u20102 variants of interest in Italy. 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