{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:55:45Z","timestamp":1791932145962,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess a series of patients receiving teprotumumab therapy and objectively quantify the rates of otologic adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective cohort study of adult patients receiving teprotumumab between May 2020 and January 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prior to treatment initiation, an ototoxicity\u2010specific audiometric battery was completed, which included conventional audiometry (frequencies 250\u20108000\u2009Hz), ultrahigh\u2010frequency audiometry (9000\u201020,000\u2009Hz), tympanometry, speech discrimination scores, and distortion product otoacoustic emissions (DPOAEs). Testing was then repeated after treatment completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 35 patients were recruited, with a median (range) age of 48.5 years (21\u201074), and 8 (22.8%) were male. The most common subjective symptom reported was a hearing decline (25.7%), followed by aural fullness (17.1%) and tinnitus (14.3%). Fourteen patients had both pre\u2010 and posttreatment audiometric data. Among them, 3 patients (21.4%) were found to have changes in standard frequency audiometry, and 10 (71.4%) had changes in high\u2010frequency audiometry, with 2 patients having changes in both. Less than half (n\u2009=\u20095) of the 11 patients with changes in standard or high\u2010frequency pure tone hearing noted subjective hearing decline. Changes in DPOAE were noted in 4 patients out of 13 (30.7%). Two patients discontinued treatment due to hearing decline. Finally, 3 patients (8.6%) were diagnosed with patulous eustachian tube (PET) by an otolaryngologist, and another 3 patients are suspected to have PET based on symptom description during ophthalmologic follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our cohort, a high incidence of otologic symptoms was found to be associated with teprotumumab usage. Subjective hearing decline, changes in ultrahigh\u2010frequency hearing as well as eustachian tube dysfunction may be encountered and suggest the potential ototoxicity of teprotumumab.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.174","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T05:02:41Z","timestamp":1674104561000},"page":"1164-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prospective Assessment of Otologic Adverse Events due to Teprotumumab: Preliminary Results"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-4532","authenticated-orcid":false,"given":"Emily","family":"Kay\u2010Rivest","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Belinsky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kozlova","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Byrd","sequence":"additional","affiliation":[{"name":"Department of Audiology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean O.","family":"McMenomey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; 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