{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:09Z","timestamp":1761007449626,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the role of a negative pressure room with a high\u2010efficiency particulate air (HEPA) filtration system on reducing aerosol exposure in common otolaryngology procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective quantification of aerosol generation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>Tertiary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The particle concentrations were measured at various times during tracheostomy tube changes with tracheostomy suctioning, nasal endoscopy with suctioning, and fiberoptic laryngoscopy (FOL), which included 5 times per procedure\u00a0in a negative pressure isolation room with a HEPA filter and additional 5 times in a nonpressure\u2010controlled room without a HEPA filter. The particle concentrations were measured from the baseline, during the procedure, and continued until 30\u2009minutes after the procedure ended. The particle concentrations were compared to the baseline concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The particle concentration significantly increased from the baseline during tracheostomy tube changes (mean difference [MD] 0.80\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\u2009p\/m<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u2009.01), tracheostomy suctioning (MD 0.78\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\u2009p\/m<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u2009.004), at 2 minutes (MD 1.29\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\u2009p\/m<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u2009.01), and 3 minutes (MD 1.3\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\u2009p\/m<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u2009.004) after suctioning. There were no significant differences in the mean particle concentrations among various time points during nasal endoscopy with suctioning and FOL neither in isolation nor nonpressure\u2010controlled rooms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A negative pressure isolation room with a HEPA filter was revealed to be safe for medical personnel inside and outside the room. Tracheostomy tube change with tracheostomy suctioning required an isolation room because this procedure generated aerosol, while nasal endoscopy with suctioning and FOL did not. Aerosol generated in an isolation room was diminished to the baseline after 4 minutes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.177","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T08:49:21Z","timestamp":1674118161000},"page":"1015-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aerosol Concentrations During Otolaryngology Procedures in a Negative Pressure Isolation Room"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-7638","authenticated-orcid":false,"given":"Kachorn","family":"Seresirikachorn","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"Endoscopic Nasal and Sinus Surgery Excellence Center King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patthrarawalai","family":"Sirinara","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine King Chulalongkorn Memorial Hospital Bangkok Thailand"},{"name":"Department of Preventive and Social Medicine, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Napadon","family":"Tangjaturonrasme","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirima","family":"Panyametheekul","sequence":"additional","affiliation":[{"name":"Department of Environmental Engineering, Faculty of Engineering Chulalongkorn University Bangkok Thailand"},{"name":"Thailand Network Center on Air Quality Management: TAQM Bangkok Thailand"},{"name":"Research Unit: HAUS IAQ Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thawat","family":"Ngamsritrakul","sequence":"additional","affiliation":[{"name":"Thailand Network Center on Air Quality Management: TAQM Bangkok Thailand"},{"name":"Research Unit: HAUS IAQ Chulalongkorn University Bangkok Thailand"},{"name":"Defense Engineering and Technology, Faculty of Engineering Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uraiwan","family":"Supaphan","sequence":"additional","affiliation":[{"name":"Occupational Health and Health Promotion Center King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thirayu","family":"Boonroung","sequence":"additional","affiliation":[{"name":"Dental Center, King Chulalongkorn Memorial Hospital The Thai Red Cross Society Bangkok 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