{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:40:55Z","timestamp":1788864055720,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare outcomes of facial nerve repair or grafting following facial nerve\u2010sacrificing procedures among patients treated with and without postoperative radiotherapy (RT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, OVID, Conference Papers Index, Cochrane Library, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Databases were searched using terms including \u201cfacial nerve,\u201d\u00a0\u201cgraft,\u201d\u00a0\u201crepair,\u201d\u00a0and \u201cradiotherapy.\u201d Abstracts mentioning facial nerve repair and evaluation of facial nerve function were included for full\u2010text review. Studies that utilized the House\u2010Brackmann or similar validated scale for evaluation of postoperative facial nerve function were selected for review. All identified studies were included in a pooled <jats:italic>t<\/jats:italic> test analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies with 142 patients were included in the systematic review. All 12 studies individually demonstrated no significant difference in facial nerve outcomes between patients who received postoperative radiation and patients who did not. A pooled <jats:italic>t<\/jats:italic> test of data from all studies also demonstrated no significant difference in postoperative facial nerve function between the postoperative RT and non\u2010RT groups (<jats:italic>t<\/jats:italic>\u00a0stat\u2009=\u20090.92, <jats:italic>p<\/jats:italic>\u2009=\u2009.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This analysis, including 12 studies, demonstrated that among patients undergoing facial nerve grafting or repair, there was no significant difference in postoperative facial nerve function between postoperative RT\u00a0and non\u2010RT patients. Due to the small sample size and variability in study methods, further studies directly comparing outcomes between patients with and without postoperative RT would be beneficial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.224","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T11:23:21Z","timestamp":1674991401000},"page":"1346-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Postoperative Radiotherapy and Facial Nerve Outcomes Following Nerve Repair: A Systematic Review"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-9418","authenticated-orcid":false,"given":"Hannah L.","family":"Kenny","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania 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