{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:03:40Z","timestamp":1773374620981,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Patient\u2010reported voice quality is an important outcome during counseling in early\u2010stage glottic cancer. However, there is a paucity of adequate longitudinal studies concerning voice outcomes. This study aimed to investigate longitudinal trajectories for patient\u2010reported voice quality and associated risk factors for treatment modalities such as transoral CO<jats:sub>2<\/jats:sub> laser microsurgery, single vocal cord irradiation, and local radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A longitudinal observational cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary cancer center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients treated for Tcis\u2010T1b, N0M0 glottic cancer were included in this study (N\u2009=\u2009294). The Voice Handicap Index was obtained at baseline and during follow\u2010up (N\u2009=\u20091944). Mixed\u2010effects models were used for investigating the different trajectories for patient\u2010reported voice quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up duration was 43.4 (SD 21.5) months. Patients received transoral CO<jats:sub>2<\/jats:sub> laser microsurgery (57.8%), single vocal cord irradiation (24.5%), or local radiotherapy (17.5%). A steeper improvement during the first year after treatment for single vocal cord irradiation (\u221215.7) and local radiotherapy (\u221212.4) was seen, compared with a more stable trajectory for laser surgery (\u22126.1). All treatment modalities showed equivalent outcomes during long\u2010term follow\u2010up. Associated risk factors for different longitudinal trajectories were age, tumor stage, and comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Longitudinal patient\u2010reported voice quality after treatment for early\u2010stage glottic cancer is heterogeneous and nonlinear. Most improvement is seen during the first year of follow\u2010up and differs between treatment modalities. No clinically significant differences in long\u2010term trajectories were found. Insight into longitudinal trajectories can enhance individual patient counseling and provide the foundation for an individualized dynamic prediction model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.263","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T01:28:19Z","timestamp":1675906099000},"page":"1463-1471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Longitudinal Patient\u2010Reported Voice Quality in Early\u2010Stage Glottic Cancer"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0900-3438","authenticated-orcid":false,"given":"Maarten C.","family":"Dorr","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniel","family":"Sewnaik","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elrozy","family":"Andrinopoulou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Erasmus MC Cancer Institute Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diako","family":"Berzenji","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie A.C.","family":"Dronkers","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone E.","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arta","family":"Hoesseini","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Tans","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Rizopoulos","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Erasmus MC Cancer Institute Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Baatenburg de Jong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinella P.J.","family":"Offerman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_4_1","unstructured":"National Comprehensive Cancer Network.\u00a02020.The Complete Library of NCCN Oncology Practice Guidelines. 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