{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:02:27Z","timestamp":1789704147565,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,8]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To determine whether an electronic health record (EHR) system can be used to identify cases of aspirin\u2010exacerbated respiratory disease (AERD) in an area outside of a regional referral center with low rates of aspirin desensitization therapy.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n Retrospective chart review single academic tertiary care hospital.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Single\u2010site academic tertiary care hospital.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Using Epic's SlicerDicer function, an algorithm was created and applied to all patient charts from 2013 to 2021. The algorithm was as follows: \u201cAllergy\/Contraindication to NSAIDs OR aspirin\u201d AND \u201cDiagnosis of Nasal polyp AND \u201cDiagnosis of Asthma.\u201d Clinical data including demographics, NSAID reaction, and specialist involvement was collected.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 54 potential cases of AERD were identified. Thirty\u2010two\u00a0were determined to have AERD after chart review, yet 12 of these patients (37.5%) had no mention of AERD within the chart. The 54 patients were stratified into 2 cohorts based on reaction to NSAIDs: respiratory (n\u2009=\u200929) or unspecified (n\u2009=\u200925). Of the patients in the respiratory reaction group, 26 were found to have clinical AERD, demonstrating a positive predictive values (PPV) of 89.7%. The overall PPV was 59.3%. Those with a respiratory reaction to NSAIDS listed in the EHR were more likely to have clinical AERD (odds ratio\u00a027.44; confidence interval\u00a06.08\u2010123.85;\n p<\/jats:italic>\n \u2009<\u20090.0001). Only 2 patients (6.3%) underwent aspirin desensitization.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n AERD remains under\u2010diagnosed in the study population. The informatics algorithm presented here has a high positive predictive value for identifying clinical AERD patients in a geographical area with low rates of aspirin desensitization and may aid in identifying candidates for expanded treatment options.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ohn.267","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T01:20:35Z","timestamp":1675128035000},"page":"253-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Algorithmic Identification of Patients With Aspirin\u2010Exacerbated Respiratory Disease Using an Electronic Health Record"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-3616","authenticated-orcid":false,"given":"Michael","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-014-2910-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-68-5-975"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22516"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.03.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.05.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12131"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.048"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22471"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12260"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000331"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.043"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.06.016"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.10.021"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0257"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2011-000583"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:09:01Z","timestamp":1789700941000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/ohn.267"],"URL":"https:\/\/doi.org\/10.1002\/ohn.267","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"assertion":[{"value":"2022-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}