{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:44:04Z","timestamp":1791945844229,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Devices for near\u2010infrared light stimulation of autofluorescence (NIRAF) allow for intraoperative identification of parathyroid glands with high sensitivity in adults. However, their performance in the pediatric population is unknown. In this case series with chart review at a tertiary academic children's hospital, we investigated pediatric patients undergoing thyroid surgery and concurrent use of a probe\u2010based NIRAF device. Thirteen patients (ages 6\u201018 years) underwent thyroid and\/or neck dissection procedures, and 2 patients had revision procedures for a total of 15 cases with the NIRAF device. Eight cases had NIRAF values that matched surgeon opinion of parathyroid tissue or histology when available. Six cases had false positive NIRAF readings (40.0%) and 1 case had false negative readings (6.7%). Compared with surgeon opinion or histology, the NIRAF device confirmed 26 of 34 parathyroid gland candidates (76.5%). These devices need further investigation in pediatric patients, whose tissues may have different autofluorescence characteristics.<\/jats:p>","DOI":"10.1002\/ohn.272","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T10:03:18Z","timestamp":1674986598000},"page":"185-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Parathyroid Autofluorescence in Pediatric Thyroid Surgery: Experience With False Positive and False Negative Results"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3525-8728","authenticated-orcid":false,"given":"Brooke M.","family":"Su\u2010Velez","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University  California Palo Alto USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery Stanford University  California Palo Alto USA"},{"name":"Children's Thyroid Center, Stanford Children's Health  California Palo Alto USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Seeley","sequence":"additional","affiliation":[{"name":"Children's Thyroid Center, Stanford Children's Health  California Palo Alto USA"},{"name":"Department of Pediatrics, Division of Pediatric Endocrinology Stanford University  California Palo Alto USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-227X","authenticated-orcid":false,"given":"Lisa A.","family":"Orloff","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University  California Palo Alto USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-3315","authenticated-orcid":false,"given":"Julia E.","family":"Noel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University  California Palo Alto USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara D.","family":"Meister","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University  California Palo Alto USA"},{"name":"Children's Thyroid Center, Stanford Children's Health  California Palo Alto USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816677527"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0460"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5338-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.09.014"},{"key":"e_1_2_8_6_1","unstructured":"US Food and Drug Administration. FDA permits marketing of two devices that detect parathyroid tissue in real\u2010time during surgery. March 24 2020 Accessed August 8 2021.https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-permits-marketing-two-devices-detect-parathyroid-tissue-real-time-during-surgery"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26500"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2018.12.044"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.4613"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003700"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-021-02269-8"},{"key":"e_1_2_8_12_1","first-page":"1166","article-title":"Intraoperative parathyroid gland identification using autofluorescence: pearls and pitfalls","volume":"2","author":"Hartl D","year":"2019","journal-title":"World J Surg Surg Res"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.06.046"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.272","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:49:19Z","timestamp":1760971759000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,29]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/ohn.272"],"URL":"https:\/\/doi.org\/10.1002\/ohn.272","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,29]]},"assertion":[{"value":"2022-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}