{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:15:58Z","timestamp":1791814558976,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objective of this study was to report outcomes for 19 consecutive patients with SMARCB1 (INI\u20101)\u2010deficient sinonasal carcinoma. Patients were treated from 2014 to 2021 and followed for a median of 22.3 months. The median overall survival (OS) and disease\u2010free survival (DFS) were 31.8 and 9.9 months, respectively. Patients with nasal cavity or maxillary sinus tumors had 84% better disease\u2010specific survival (DSS) (hazard ratio [HR], 0.136; 95% confidence interval [CI], 0.028\u20100.66;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.005) and 71% better DFS (HR, 0.29; 95% CI, 0.097\u20100.84;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.041) than patients with other sinonasal sites. Patients who received induction chemotherapy were 76% less likely to die of disease (DSS HR, 0.241; 95% CI, 0.058\u20101.00;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.047). In the largest single\u2010institution study of SMARCB1\u2010deficient sinonasal carcinoma to date, OS and DFS approached 3 years and 1 year, respectively, but were better for nasal cavity and maxillary sinus tumors. Patients may benefit from induction chemotherapy.\n                  <\/jats:p>","DOI":"10.1002\/ohn.310","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T04:55:39Z","timestamp":1677646539000},"page":"435-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of Clinical Factors and Treatments on SMARCB1 (INI\u20101)\u2010Deficient Sinonasal Carcinoma"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-1706","authenticated-orcid":false,"given":"Kevin J.","family":"Contrera","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Shakibai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3903-8204","authenticated-orcid":false,"given":"Shirley Y.","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4418-3705","authenticated-orcid":false,"given":"Maria K.","family":"Gule\u2010Monroe","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1414-1878","authenticated-orcid":false,"given":"Dianna","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-5840","authenticated-orcid":false,"given":"Bledi","family":"Brahimaj","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle D.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-215X","authenticated-orcid":false,"given":"Renata","family":"Ferrarotto","sequence":"additional","affiliation":[{"name":"Department of Thoracic\u2010Head and Neck Medical Oncology University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5977-6004","authenticated-orcid":false,"given":"Jack","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-0380","authenticated-orcid":false,"given":"Brandon","family":"Gunn","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2722-2781","authenticated-orcid":false,"given":"Shaan","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-3645","authenticated-orcid":false,"given":"Franco","family":"DeMonte","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3241-2440","authenticated-orcid":false,"given":"Ehab Y.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"782","article-title":"SWI\/SNF alterations in poorly\u2010differentiated sinonasal carcinomas: an institutional experience identifying INI1\u2010and BRG1\u2010deficient carcinomas via immunohistochemistry","volume":"101","author":"McLean\u2010Holden A","year":"2021","journal-title":"Lab Invest"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"9","article-title":"Sinonasal tumor pathology: what's new?","volume":"109","author":"Franchi A","year":"2017","journal-title":"Pathologica"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000797"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.08.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001428"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000285"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"784","article-title":"Smarcb1(INI\u20101)\u2010deficient head and neck carcinomas in adults\u2014a tertiary care cancer center series of 17 cases","volume":"101","author":"Mittal N","year":"2021","journal-title":"Lab Invest"},{"issue":"1","key":"e_1_2_11_9_1","article-title":"Can INI\u20101 (SMARCB1) gene determine the survival outcomes in sinonasal undifferentiated carcinoma?","volume":"80","author":"Chitguppi C","year":"2019","journal-title":"J Neurolog Surg Part B Skull Base"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00353"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26150"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_11_13_1","first-page":"13","volume-title":"American Joint Committee on Cancer Cancer Staging Manual","author":"Amin 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Immunotherapy with chemotherapy and chemoradiation for advanced squamous cancer of nasal cavity\/paranasal sinuses (I\u2010NAPA). U.S. National Library of Medicine. 2022. Accessed September 11 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05027633"},{"key":"e_1_2_11_23_1","unstructured":"HannaEY. Phase II trial of induction therapy with docetaxel cisplatin and fluorouracil in previously untreated patients with locally advanced squamous cell carcinoma and\/or poorly differentiated carcinoma of the nasal cavity and\/or paranasal sinuses. U.S. National Library of Medicine. 2021. Accessed October 13 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00707473"},{"key":"e_1_2_11_24_1","unstructured":"ECOG\u2010ACRIN Cancer Research Group. Phase II randomized trial of neo\u2010adjuvant chemotherapy followed by surgery and post\u2010operative radiation versus surgery and post\u2010operative radiation for organ preservation of T3 and T4a nasal and paranasal sinus squamous cell carcinoma. U.S. National Library of Medicine. 2022. Accessed September 11 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00707473"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30451-4"},{"key":"e_1_2_11_26_1","unstructured":"LeeV. Induction chemotherapy and tazemetostat for locally advanced SMARCB1\u2010deficient sinonasal carcinoma. U.S. National Library of Medicine. 2022. Accessed September 1 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05151588"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.310","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:10:35Z","timestamp":1789701035000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/ohn.310"],"URL":"https:\/\/doi.org\/10.1002\/ohn.310","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]},"assertion":[{"value":"2022-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}