{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:28:24Z","timestamp":1772184504093,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Macrolide antibiotics are often used to prevent infection and inflammation after functional endoscopic sinus surgery for the treatment of chronic rhinosinusitis (CRS). The purpose of this study was to investigate the anti\u2010inflammatory and antibacterial effects of the clarithromycin\u2010loaded poly(\u2010lactide) (CLA\u2010PLLA) membrane and its mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Animal Experiment Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the difference between poly(<jats:sc>l<\/jats:sc>\u2010lactide) (PLLA) and CLA\u2010PLLA membranes by observing the morphology of fibrous scaffolds, measuring water contact angle, tensile strength, and drug release capacity, and evaluating the antimicrobial activity of CLA\u2010PLLA. Twenty\u2010four rabbits were divided into a PLLA group and a CLA\u2010PLLA group after establishing CRS models. Another 5 normal rabbits comprised the control group. After 3 months, we placed the PLLA membrane in the nasal cavity of the PLLA group and the CLA\u2010PLLA membrane in the CLA\u2010PLLA group. Then, 14 days later, we evaluated the histological and ultrastructural changes in the sinus mucosa, protein, and messenger RNA (mRNA) levels of interleukin (IL)\u20104, IL\u20108, tumor necrosis factor\u2010\u03b1, transforming growth factor\u2010\u03b21, \u03b1\u2010smooth muscle actin, and type I collagen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CLA\u2010PLLA membrane showed no significant difference in physical performance to the PLLA membrane, which continuously released 95% of the clarithromycin (CLA) for 2 months. The CLA\u2010PLLA membrane had significant bacteriostatic properties that can improve the morphology of mucosal tissues, and inhibit protein and mRNA expression of inflammatory cytokines. In addition, CLA\u2010PLLA also inhibited the expression of fibrosis\u2010associated marker molecules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CLA\u2010PLLA membrane released CLA\u00a0slowly and continuously, providing antibacterial, anti\u2010inflammatory, and antifibrotic effects in a rabbit model of postoperative CRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.370","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T04:19:57Z","timestamp":1685247597000},"page":"1335-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antibacterial and Anti\u2010inflammatory Effects of Clarithromycin\u2010Loaded Poly(<scp>l<\/scp>\u2010Lactide) Membrane in Rabbit Postoperation Model of Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-3164","authenticated-orcid":false,"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"Nanjing 4th Retired Cadres Retreat Jiangsu Military Region Nanjing Jiangsu China"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Changhai Hospital Naval Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery No. 905 Hospital of PLA Navy Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Changhai Hospital Naval Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoyu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Changhai Hospital Naval Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9387-2120","authenticated-orcid":false,"given":"Bijun","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Urology, The 903rd PLA Hospital Hangzhou Medical College Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengjing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Changhai Hospital Naval Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Changhai Hospital Naval Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Changhai Hospital Naval Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109991368"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2_suppl.41S"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.238.49"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2015.08.014"},{"issue":"6","key":"e_1_2_8_7_1","first-page":"420","article-title":"Antibiotic usage in chronic rhinosinusitis: analysis of national primary care electronic health records","volume":"57","author":"Hopkins C","year":"2019","journal-title":"Rhinology"},{"issue":"4","key":"e_1_2_8_8_1","first-page":"252","article-title":"Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic","volume":"57","author":"Williamson E","year":"2019","journal-title":"Rhinology"},{"issue":"12","key":"e_1_2_8_9_1","first-page":"1364","article-title":"Mechanism and application of macrolide antibiotics in treatment of chronic rhinosinusitis","volume":"39","author":"Zhang T","year":"2018","journal-title":"Acad J Sec Mil Med Univ"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.05.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2012.12.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22666"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/858045"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201200452"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111166"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200012000-00021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.10.758"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310005110"},{"key":"e_1_2_8_19_1","volume-title":"Endoscopic Sinus Surgery: Anatomy, Three\u2010dimensional Reconstruction, and Surgical Technique","author":"Wormald PJ","year":"2008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb01195.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03767.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3136"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2018.10.005"},{"issue":"2","key":"e_1_2_8_24_1","first-page":"92","article-title":"Guidelines for diagnosis and treatment of chronic rhinosinusitis (2012, Kunming)","volume":"48","author":"Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery;\u00a0Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association","year":"2013","journal-title":"Chin J Otorhinolaryngol Head Neck Surg"},{"issue":"29","key":"e_1_2_8_25_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens WJ","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin19.404"},{"issue":"6","key":"e_1_2_8_27_1","first-page":"550","article-title":"Add\u2010on effect of clarithromycin to oral steroids as post\u2010operative therapy for chronic rhinosinusitis with nasal polyps: a randomised controlled trial","volume":"58","author":"Lin CF","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00078-09"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1917"},{"issue":"9","key":"e_1_2_8_30_1","first-page":"5S","article-title":"Clinical implications of the immunomodulatory effects of macrolides","volume":"117","author":"Tamaoki J","year":"2004","journal-title":"Am J Med"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(03)00342-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.10.010"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.05.012"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:01:58Z","timestamp":1760968918000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,28]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/ohn.370"],"URL":"https:\/\/doi.org\/10.1002\/ohn.370","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,28]]},"assertion":[{"value":"2022-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}