{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:36:15Z","timestamp":1790699775262,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze evidence supporting an association between immune\u2010related diseases and M\u00e9ni\u00e8re's disease (MD) since it has long been thought to be related to autoimmune disorders and allergies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>We retrieved records from Pubmed, Web of Science, Scopus, and Cochrane Library to identify studies published between January 2002 and October 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Articles were independently assessed by 2 reviewers and verified by a third reviewer. Published cross\u2010sectional studies, cohort\/longitudinal studies, case series, and noncomparative cohort studies were considered eligible for inclusion. We conducted a systematic review and meta\u2010analysis according to a registered protocol on the International Prospective Register of Systematic Reviews and Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses guidelines. Selected studies were classified into 2 groups: epidemiological and genetic association studies. Relative frequencies and odds ratios (ORs) for each autoinflammatory\/autoimmune disease or genetic marker reported to be associated with MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen studies from 6 countries met our inclusion criteria. Nine are epidemiological studies and 6 are genetic association studies. The epidemiological studies were used to perform 3 different meta\u2010analyses. Airway allergic disease and autoimmune thyroid disease showed a significant association with MD (OR\u2009=\u20092.27 [2.08\u20102.48] and OR\u2009=\u20091.35 [1.25\u20101.46]); while rheumatoid arthritis did not (OR\u2009=\u20090.63 [0.28\u20101.41]). Other comorbidities also showed a significant association with MD like chronic obstructive pulmonary disease, vitiligo, fibromyalgia, arthritis, and psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Epidemiological evidence supports an association between MD and immune\u2010related disorders in European and Asian populations, with population\u2010specific effects. The evaluation of thyroid diseases, airway allergic diseases, and other inflammatory diseases should be implemented in the clinical management of MD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.386","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T21:49:21Z","timestamp":1686088161000},"page":"1122-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Immune\u2010Related Disorders Associated With M\u00e9ni\u00e8re's\u00a0Disease: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-1430","authenticated-orcid":false,"given":"Jose A.","family":"Lopez\u2010Escamez","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology, Instituto de Investigaci\u00f3n Biosanitaria, ibs.GRANADA Universidad de Granada Granada Spain"},{"name":"Meniere's Disease Neuroscience 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