{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:01:21Z","timestamp":1788804081755,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy and safety of remimazolam with those of propofol for drug\u2010induced sleep endoscopy (DISE) in patients with obstructive sleep apnea\u2010hypopnea syndrome (OSAHS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective, single\u2010center, randomized clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Xiangya Hospital of Central South University.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with OSAHS receiving DISE were randomly assigned to either the remimazolam or propofol group. The primary outcome was the incidence of hypoxemia (pulse oxygen saturation [SpO<jats:sub>2<\/jats:sub>]\u2009&lt;\u200990%) during DISE. The secondary outcomes were the incidence of severe hypoxemia (SpO<jats:sub>2<\/jats:sub>\u2009&lt;\u200980%), the minimal value of SpO<jats:sub>2<\/jats:sub>, sedation success rate (completion of DISE according to the medication regimen), and incidence of events of interest (including injection pain, bradycardia, and decreased respiratory rate).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four patients were included in this study. The incidence of hypoxemia was significantly lower in the remimazolam than in the propofol group (25.00% vs\u00a062.50%, respectively; relative risk, 0.40; 95% confidence interval [CI], 0.20\u20100.74; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). There was no significant difference in the sedation success rate between the remimazolam and propofol groups (96.88% vs\u00a081.25%, respectively; relative risk, 1.19; 95% CI, 1.01\u20101.50; <jats:italic>p<\/jats:italic>\u2009=\u2009.10). The incidence of at least 1 event of interest was lower in the remimazolam than in the propofol group (43.75% vs\u00a096.88%, respectively; relative risk, 0.45; 95% CI, 0.29\u20100.63; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Remimazolam can present satisfactory sedative efficacy in DISE, with a lower incidence of hypoxemia and a higher safety profile than propofol.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.387","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T10:00:53Z","timestamp":1685700053000},"page":"1356-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of Remimazolam and Propofol for Drug\u2010Induced Sleep Endoscopy: A Randomized Clinical 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